Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts

Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays usi...

Full description

Saved in:
Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2011-01, Vol.2011 (2011), p.1-9
Main Authors: dos Santos, Lourdes Campaner, Colus, Ilce Mara Syllos, Vilegas, Wagner, Varanda, Eliana Aparecida, Calvo, Tamara Regina, Cardoso, Cássia Regina Primila, da Silva Moura, Adriana Candido
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antimicrobial agents
Chemical analysis
Chemicals
Chromatography
Flavonoids
Herbal medicine
Indigo
Indigofera
Kaempferol
Kinases
Mass spectrometry
Mutagenicity
Mutation
NMR
Nuclear magnetic resonance
Original
Quercetin
Salmonella
Scientific imaging
Solvents
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.
ISSN:1741-427X
1741-4288
DOI:10.1093/ecam/nep123