Reliability of the modified hammersmith functional motor scale in young children with spinal muscular atrophy

Introduction: The test–retest reliability of the Modified Hammersmith Functional Motor Scale (MHFMS) in children with spinal muscular atrophy (SMA) ≤30 months of age was assessed. The age at which typically developing children (TD) achieve maximum MHFMS scores was also studied. Methods: Twenty‐two c...

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Bibliographic Details
Published in:Muscle & nerve 2011-08, Vol.44 (2), p.246-251
Main Authors: Krosschell, Kristin J., Scott, Charles B., Maczulski, Jo Anne, Lewelt, Aga J., Reyna, Sandra P., Swoboda, Kathryn J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child, Preschool
Diseases of striated muscles. Neuromuscular diseases
Female
Fundamental and applied biological sciences. Psychology
Humans
Infant
Male
Medical sciences
MHFMS
Modified Hammersmith Functional Motor Scale
Modified Hammersmith Functional Motor Scale, outcome, spinal muscular atrophy, test–retest reliability
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Motor Skills - physiology
Neurology
outcome
Reproducibility of Results
Spinal Muscular Atrophies of Childhood - physiopathology
spinal muscular atrophy
test-retest reliability
Vertebrates: nervous system and sense organs
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Summary:Introduction: The test–retest reliability of the Modified Hammersmith Functional Motor Scale (MHFMS) in children with spinal muscular atrophy (SMA) ≤30 months of age was assessed. The age at which typically developing children (TD) achieve maximum MHFMS scores was also studied. Methods: Twenty‐two children with SMA type II [mean age (SD) = 20 (5) months, range 9–30 months) were tested twice using the MHFMS. Twenty‐five TD children [mean age (SD) = 18 (7) months, range 9–30 months) were tested once. Results: The average difference between MHFMS scores for SMA children was 0.18 [first assessment: mean (SD) = 12.8 (9.8); second assessment: mean (SD) = 13.0 (8.8)]. Reliability was excellent (ICC1,3 = 0.96, SEM 1.86). TD participants had MHFMS scores ranging from 36 to 40 [mean (SD) = 39.2 (1.2)] and achieved maximum test scores at 12 months of age. Discussion: MHFMS scores in young children with SMA type II showed excellent test–retest stability. This suggests that the MHFMS can be used reliably in this younger population for clinical trials and follow‐up. Muscle Nerve, 2011
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.22040