Antidiabetic Properties of Azardiracta indica and Bougainvillea spectabilis : In Vivo Studies in Murine Diabetes Model

Diabetes mellitus is a metabolic syndrome characterized by an increase in the blood glucose level. Treatment of diabetes is complicated due to multifactorial nature of the disease. Azadirachta indica Adr. Juss and Bougainvillea spectabilis are reported to have medicinal values including antidiabetic...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2011-01, Vol.2011 (2011), p.1-9
Main Authors: Bhat, Menakshi, Kothiwale, Sandeepkumar K., Tirmale, Amruta R., Bhargava, Shobha Y., Joshi, Bimba N.
Format: Article
Language:English
Subjects:
Animal models
Animals
Antidiabetics
Blood glucose
Bougainvillea spectabilis
Chloroform
Decapoda
Diabetes
Diabetes mellitus
Enzymes
Fasting
Glucose
Glucose 6 phosphate dehydrogenase
Glucose dehydrogenase
Glucose tolerance
Glucosephosphate dehydrogenase
Glucosidase
Glycogen
Hyperglycemia
Insulin
Insulin resistance
Intestine
Liver
Metabolic disorders
Metabolic syndrome
Metabolism
Muscles
Original
Peptides
Rodents
Skeletal muscle
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Summary:Diabetes mellitus is a metabolic syndrome characterized by an increase in the blood glucose level. Treatment of diabetes is complicated due to multifactorial nature of the disease. Azadirachta indica Adr. Juss and Bougainvillea spectabilis are reported to have medicinal values including antidiabetic properties. In the present study using in vivo diabetic murine model, A. indica and B. spectabilis chloroform, methanolic and aqueous extracts were investigated for the biochemical parameters important for controlling diabetes. It was found that A. indica chloroform extract and B. spectabilis aqueous, methanolic extracts showed a good oral glucose tolerance and significantly reduced the intestinal glucosidase activity. Interestingly, A. indica chloroform and B. spectabilis aqueous extracts showed significant increase in glucose-6-phosphate dehydrogenase activity and hepatic, skeletal muscle glycogen content after 21 days of treatment. In immunohistochemical analysis, we observed a regeneration of insulin-producing cells and corresponding increase in the plasma insulin and c-peptide levels with the treatment of A. indica chloroform and B. spectabilis aqueous, methanolic extracts. Analyzing the results, it is clear that A. indica chloroform and B. spectabilis aqueous extracts are good candidates for developing new neutraceuticals treatment for diabetes.
ISSN:1741-427X
1741-4288
DOI:10.1093/ecam/nep033