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Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma
Background: Circulating endothelial cells (CECs) are a candidate biomarker for monitoring angiogenesis in cancer. Circulating endothelial cell subsets are mobilised by angiogenic mediators. Because of the highly angiogenic phenotype of renal cell carcinoma (RCC), we sought to assess the potential of...
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| Published in: | British journal of cancer 2011-06, Vol.105 (1), p.112-117 |
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| container_end_page | 117 |
| container_issue | 1 |
| container_start_page | 112 |
| container_title | British journal of cancer |
| container_volume | 105 |
| creator | Bhatt, R S Zurita, A J O'Neill, A Norden-Zfoni, A Zhang, L Wu, H K Wen, P Y George, D Sukhatme, V P Atkins, M B Heymach, J V |
| description | Background:
Circulating endothelial cells (CECs) are a candidate biomarker for monitoring angiogenesis in cancer. Circulating endothelial cell subsets are mobilised by angiogenic mediators. Because of the highly angiogenic phenotype of renal cell carcinoma (RCC), we sought to assess the potential of CECs as a marker of RCC in patients with von Hippel-Lindau (VHL) disease and those with sporadic RCC.
Methods:
We performed multicolour flow cytometry to enumerate CECs in patients with RCC, patients with VHL disease with and without RCC, and normal subjects. Two subsets of CECs were evaluated: mature CECs (mCECs) and circulating endothelial progenitors (CEPs).
Results:
In patients with VHL disease and RCC and those with sporadic RCC (
N
=10), CEPs and the CEP:mCEC ratio were higher than in normal subjects (
N
=17) (median CEPs: 0.97
vs
0.19 cells μl
−1
, respectively,
P |
| doi_str_mv | 10.1038/bjc.2011.186 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3137404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>874296557</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-382589ed716d00784a2e78490f33464bf66efa98eebc27398bce11a1f4c1463a3</originalsourceid><addsrcrecordid>eNp1kc2LFDEQxYMo7rh68yxBWLzYY746SV8EWVZ3YcCLnkM6XT2boTtpk-4F_3vTzDirgpcKRf3yqh4PodeUbCnh-kN7cFtGKN1SLZ-gDa05q6hm6inaEEJURRpGLtCLnA-lbYhWz9EFo1JxqZoNynfBJbAZOjzG1g8-29nHgGOPnU9uGUob9hhCF-d7GLwd8JTiHoKfY8rYB_xQ6Fs_TTBUOx86u-DO51UR29DhBKF8cTCUYpPzIY72JXrW2yHDq9N7ib5_vvl2fVvtvn65u_60q1xN-FxxzWrdQKeo7IoRLSyDUhvScy6kaHspobeNBmgdU7zRrQNKLe2Fo0Jyyy_Rx6PutLQjdA7CnOxgpuRHm36aaL35exL8vdnHB8MpV4KIIvDuJJDijwXybEafVy82QFyy0UqwRta1KuTbf8hDXFKxvkJaKFLLFXp_hFyKOSfoz6dQYtYsTcnSrFmakmXB3_x5_hn-HV4Brk6Azc4OfbLB-fzICc5kU682qiOXyyjsIT0e95_F-MgHOy8JzoIFWpkV-QV6ksMB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>878470567</pqid></control><display><type>article</type><title>Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma</title><source>PubMed Central</source><creator>Bhatt, R S ; Zurita, A J ; O'Neill, A ; Norden-Zfoni, A ; Zhang, L ; Wu, H K ; Wen, P Y ; George, D ; Sukhatme, V P ; Atkins, M B ; Heymach, J V</creator><creatorcontrib>Bhatt, R S ; Zurita, A J ; O'Neill, A ; Norden-Zfoni, A ; Zhang, L ; Wu, H K ; Wen, P Y ; George, D ; Sukhatme, V P ; Atkins, M B ; Heymach, J V</creatorcontrib><description>Background:
Circulating endothelial cells (CECs) are a candidate biomarker for monitoring angiogenesis in cancer. Circulating endothelial cell subsets are mobilised by angiogenic mediators. Because of the highly angiogenic phenotype of renal cell carcinoma (RCC), we sought to assess the potential of CECs as a marker of RCC in patients with von Hippel-Lindau (VHL) disease and those with sporadic RCC.
Methods:
We performed multicolour flow cytometry to enumerate CECs in patients with RCC, patients with VHL disease with and without RCC, and normal subjects. Two subsets of CECs were evaluated: mature CECs (mCECs) and circulating endothelial progenitors (CEPs).
Results:
In patients with VHL disease and RCC and those with sporadic RCC (
N
=10), CEPs and the CEP:mCEC ratio were higher than in normal subjects (
N
=17) (median CEPs: 0.97
vs
0.19 cells μl
−1
, respectively,
P
<0.01; median CEP:mCEC: 0.92
vs
0.58, respectively,
P
=0.04). However, in patients with VHL without RCC, CECs were not increased. In paired pre- and post-nephrectomy RCC patient samples (
N
=20), CEPs decreased after surgery (median difference 0.02 cells μl
−1
, −0.06 to 1.2;
P
=0.05).
Conclusion:
Circulating endothelial progenitors were elevated in RCC, but not in patients with VHL without RCC. Circulating endothelial progenitor enumeration merits further investigation as a monitoring strategy for patients with VHL.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2011.186</identifier><identifier>PMID: 21673679</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2421 ; 692/699/67/589/1588/1351 ; 692/699/75/593 ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Renal Cell - pathology ; Case-Control Studies ; Drug Resistance ; Endothelial Cells - pathology ; Epidemiology ; Hematopoietic Stem Cell Mobilization ; Humans ; Kidney Neoplasms - pathology ; Kidneys ; Medical sciences ; Molecular Diagnostics ; Molecular Medicine ; Neoplastic Stem Cells - pathology ; Nephrology. Urinary tract diseases ; Oncology ; Survival Rate ; Treatment Outcome ; Tumors ; Tumors of the urinary system ; von Hippel-Lindau Disease - pathology</subject><ispartof>British journal of cancer, 2011-06, Vol.105 (1), p.112-117</ispartof><rights>The Author(s) 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 28, 2011</rights><rights>Copyright © 2011 Cancer Research UK 2011 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-382589ed716d00784a2e78490f33464bf66efa98eebc27398bce11a1f4c1463a3</citedby><cites>FETCH-LOGICAL-c503t-382589ed716d00784a2e78490f33464bf66efa98eebc27398bce11a1f4c1463a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137404/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137404/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24326954$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21673679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhatt, R S</creatorcontrib><creatorcontrib>Zurita, A J</creatorcontrib><creatorcontrib>O'Neill, A</creatorcontrib><creatorcontrib>Norden-Zfoni, A</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><creatorcontrib>Wu, H K</creatorcontrib><creatorcontrib>Wen, P Y</creatorcontrib><creatorcontrib>George, D</creatorcontrib><creatorcontrib>Sukhatme, V P</creatorcontrib><creatorcontrib>Atkins, M B</creatorcontrib><creatorcontrib>Heymach, J V</creatorcontrib><title>Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Circulating endothelial cells (CECs) are a candidate biomarker for monitoring angiogenesis in cancer. Circulating endothelial cell subsets are mobilised by angiogenic mediators. Because of the highly angiogenic phenotype of renal cell carcinoma (RCC), we sought to assess the potential of CECs as a marker of RCC in patients with von Hippel-Lindau (VHL) disease and those with sporadic RCC.
Methods:
We performed multicolour flow cytometry to enumerate CECs in patients with RCC, patients with VHL disease with and without RCC, and normal subjects. Two subsets of CECs were evaluated: mature CECs (mCECs) and circulating endothelial progenitors (CEPs).
Results:
In patients with VHL disease and RCC and those with sporadic RCC (
N
=10), CEPs and the CEP:mCEC ratio were higher than in normal subjects (
N
=17) (median CEPs: 0.97
vs
0.19 cells μl
−1
, respectively,
P
<0.01; median CEP:mCEC: 0.92
vs
0.58, respectively,
P
=0.04). However, in patients with VHL without RCC, CECs were not increased. In paired pre- and post-nephrectomy RCC patient samples (
N
=20), CEPs decreased after surgery (median difference 0.02 cells μl
−1
, −0.06 to 1.2;
P
=0.05).
Conclusion:
Circulating endothelial progenitors were elevated in RCC, but not in patients with VHL without RCC. Circulating endothelial progenitor enumeration merits further investigation as a monitoring strategy for patients with VHL.</description><subject>692/53/2421</subject><subject>692/699/67/589/1588/1351</subject><subject>692/699/75/593</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Case-Control Studies</subject><subject>Drug Resistance</subject><subject>Endothelial Cells - pathology</subject><subject>Epidemiology</subject><subject>Hematopoietic Stem Cell Mobilization</subject><subject>Humans</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Oncology</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>von Hippel-Lindau Disease - pathology</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kc2LFDEQxYMo7rh68yxBWLzYY746SV8EWVZ3YcCLnkM6XT2boTtpk-4F_3vTzDirgpcKRf3yqh4PodeUbCnh-kN7cFtGKN1SLZ-gDa05q6hm6inaEEJURRpGLtCLnA-lbYhWz9EFo1JxqZoNynfBJbAZOjzG1g8-29nHgGOPnU9uGUob9hhCF-d7GLwd8JTiHoKfY8rYB_xQ6Fs_TTBUOx86u-DO51UR29DhBKF8cTCUYpPzIY72JXrW2yHDq9N7ib5_vvl2fVvtvn65u_60q1xN-FxxzWrdQKeo7IoRLSyDUhvScy6kaHspobeNBmgdU7zRrQNKLe2Fo0Jyyy_Rx6PutLQjdA7CnOxgpuRHm36aaL35exL8vdnHB8MpV4KIIvDuJJDijwXybEafVy82QFyy0UqwRta1KuTbf8hDXFKxvkJaKFLLFXp_hFyKOSfoz6dQYtYsTcnSrFmakmXB3_x5_hn-HV4Brk6Azc4OfbLB-fzICc5kU682qiOXyyjsIT0e95_F-MgHOy8JzoIFWpkV-QV6ksMB</recordid><startdate>20110628</startdate><enddate>20110628</enddate><creator>Bhatt, R S</creator><creator>Zurita, A J</creator><creator>O'Neill, A</creator><creator>Norden-Zfoni, A</creator><creator>Zhang, L</creator><creator>Wu, H K</creator><creator>Wen, P Y</creator><creator>George, D</creator><creator>Sukhatme, V P</creator><creator>Atkins, M B</creator><creator>Heymach, J V</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110628</creationdate><title>Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma</title><author>Bhatt, R S ; Zurita, A J ; O'Neill, A ; Norden-Zfoni, A ; Zhang, L ; Wu, H K ; Wen, P Y ; George, D ; Sukhatme, V P ; Atkins, M B ; Heymach, J V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-382589ed716d00784a2e78490f33464bf66efa98eebc27398bce11a1f4c1463a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>692/53/2421</topic><topic>692/699/67/589/1588/1351</topic><topic>692/699/75/593</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Case-Control Studies</topic><topic>Drug Resistance</topic><topic>Endothelial Cells - pathology</topic><topic>Epidemiology</topic><topic>Hematopoietic Stem Cell Mobilization</topic><topic>Humans</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Medical sciences</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Oncology</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>von Hippel-Lindau Disease - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhatt, R S</creatorcontrib><creatorcontrib>Zurita, A J</creatorcontrib><creatorcontrib>O'Neill, A</creatorcontrib><creatorcontrib>Norden-Zfoni, A</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><creatorcontrib>Wu, H K</creatorcontrib><creatorcontrib>Wen, P Y</creatorcontrib><creatorcontrib>George, D</creatorcontrib><creatorcontrib>Sukhatme, V P</creatorcontrib><creatorcontrib>Atkins, M B</creatorcontrib><creatorcontrib>Heymach, J V</creatorcontrib><collection>SpringerOpen</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhatt, R S</au><au>Zurita, A J</au><au>O'Neill, A</au><au>Norden-Zfoni, A</au><au>Zhang, L</au><au>Wu, H K</au><au>Wen, P Y</au><au>George, D</au><au>Sukhatme, V P</au><au>Atkins, M B</au><au>Heymach, J V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2011-06-28</date><risdate>2011</risdate><volume>105</volume><issue>1</issue><spage>112</spage><epage>117</epage><pages>112-117</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Circulating endothelial cells (CECs) are a candidate biomarker for monitoring angiogenesis in cancer. Circulating endothelial cell subsets are mobilised by angiogenic mediators. Because of the highly angiogenic phenotype of renal cell carcinoma (RCC), we sought to assess the potential of CECs as a marker of RCC in patients with von Hippel-Lindau (VHL) disease and those with sporadic RCC.
Methods:
We performed multicolour flow cytometry to enumerate CECs in patients with RCC, patients with VHL disease with and without RCC, and normal subjects. Two subsets of CECs were evaluated: mature CECs (mCECs) and circulating endothelial progenitors (CEPs).
Results:
In patients with VHL disease and RCC and those with sporadic RCC (
N
=10), CEPs and the CEP:mCEC ratio were higher than in normal subjects (
N
=17) (median CEPs: 0.97
vs
0.19 cells μl
−1
, respectively,
P
<0.01; median CEP:mCEC: 0.92
vs
0.58, respectively,
P
=0.04). However, in patients with VHL without RCC, CECs were not increased. In paired pre- and post-nephrectomy RCC patient samples (
N
=20), CEPs decreased after surgery (median difference 0.02 cells μl
−1
, −0.06 to 1.2;
P
=0.05).
Conclusion:
Circulating endothelial progenitors were elevated in RCC, but not in patients with VHL without RCC. Circulating endothelial progenitor enumeration merits further investigation as a monitoring strategy for patients with VHL.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21673679</pmid><doi>10.1038/bjc.2011.186</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 2011-06, Vol.105 (1), p.112-117 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3137404 |
| source | PubMed Central |
| subjects | 692/53/2421 692/699/67/589/1588/1351 692/699/75/593 Biological and medical sciences Biomarkers, Tumor - analysis Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Renal Cell - pathology Case-Control Studies Drug Resistance Endothelial Cells - pathology Epidemiology Hematopoietic Stem Cell Mobilization Humans Kidney Neoplasms - pathology Kidneys Medical sciences Molecular Diagnostics Molecular Medicine Neoplastic Stem Cells - pathology Nephrology. Urinary tract diseases Oncology Survival Rate Treatment Outcome Tumors Tumors of the urinary system von Hippel-Lindau Disease - pathology |
| title | Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma |
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