Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT

Background: Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision to use HRT to cover the period of oestrogen deprivation up to 50 years of age i...

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Bibliographic Details
Published in:British journal of cancer 2011-06, Vol.105 (1), p.22-27
Main Authors: Challberg, J, Ashcroft, L, Lalloo, F, Eckersley, B, Clayton, R, Hopwood, P, Selby, P, Howell, A, Evans, D G
Format: Article
Language:English
Subjects:
692/699/67/1517/1709
692/700/1421/2770
692/700/565/1331/238
692/700/565/545/546
Adult
Age
Aged
Aged, 80 and over
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Bone
Bone and Bones
Bone cancer
Bone density
Bone loss
BRCA1 protein
BRCA2 protein
Breast cancer
Cancer
Cancer Research
Cardiovascular diseases
Clinical Study
Diseases of the osteoarticular system
Drug Resistance
Dual energy X-ray absorptiometry
Epidemiology
Estrogen Replacement Therapy
Estrogens
Female
Females
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Health Status
Humans
Inventories
Medical sciences
Menopause
Middle Aged
Molecular Medicine
Mutation
Oncology
Osteoporosis. Osteomalacia. Paget disease
Ovarian cancer
Ovarian carcinoma
Ovarian Neoplasms - genetics
Ovarian Neoplasms - prevention & control
Ovariectomy
Postoperative Care
Reviews
Risk Assessment
Risk Factors
Risk reduction
Salpingostomy
Treatment Outcome
Tumors
Young Adult
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Summary:Background: Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision to use HRT to cover the period of oestrogen deprivation up to 50 years of age is difficult because of balancing the considerations of breast cancer risk, bone and cardiovascular health. Methods: We reviewed by questionnaire 289 women after BRRSPO aged ⩽48 years because of high ovarian cancer risk; 212 (73%) of women responded. Results: Previous HRT users ( n =67) had significantly worse endocrine symptom scores than 67 current users ( P =0.006). A total of 123 (58%) of women had ⩾24 months of oestrogen deprivation
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2011.202