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Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT
Background: Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision to use HRT to cover the period of oestrogen deprivation up to 50 years of age i...
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| Published in: | British journal of cancer 2011-06, Vol.105 (1), p.22-27 |
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| container_end_page | 27 |
| container_issue | 1 |
| container_start_page | 22 |
| container_title | British journal of cancer |
| container_volume | 105 |
| creator | Challberg, J Ashcroft, L Lalloo, F Eckersley, B Clayton, R Hopwood, P Selby, P Howell, A Evans, D G |
| description | Background:
Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision to use HRT to cover the period of oestrogen deprivation up to 50 years of age is difficult because of balancing the considerations of breast cancer risk, bone and cardiovascular health.
Methods:
We reviewed by questionnaire 289 women after BRRSPO aged ⩽48 years because of high ovarian cancer risk; 212 (73%) of women responded.
Results:
Previous HRT users (
n
=67) had significantly worse endocrine symptom scores than 67 current users (
P
=0.006). A total of 123 (58%) of women had ⩾24 months of oestrogen deprivation |
| doi_str_mv | 10.1038/bjc.2011.202 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3137416</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>874296544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-6a0ce4c5234e89c9cfd98b5ad385df5dfa74be396d259027be7723b7bbdde7f83</originalsourceid><addsrcrecordid>eNqFkl1rFDEUhgdR7Fq981qCIN44NV8zyXghlKJWqAhSr0OSObOb7UwyTWYs-2f8rWbYtbUiCOGEkzy855zkLYrnBJ8QzORbs7UnFBOSA31QrEjFaEkkFQ-LFcZYlLih-Kh4ktI2pw2W4nFxREld8VqKVfHzC_gw6jnpHqXdME5hSEj7FpngAW1A99MGOY9uwgAezb6FOOkr59counSFIrSzXTLjej1BXFR0P-aTUIYwbkIEmyV371Bya-86Z7Wf7munNENaSkybkAD5MKFDhfNvl0-LR53uEzw77MfF948fLs_Oy4uvnz6fnV6UtiJ4KmuNLXBbUcZBNraxXdtIU-mWyart8tKCG2BN3dKqwVQYEIIyI4xpWxCdZMfF-73uOJsBWgt-yrOoMbpBx50K2qn7N95t1Dr8UIwwwUmdBV4fBGK4zgNNanDJQt9rD2FOSkqGOSEV_z8pOG3y9yzky7_IbZijz--QIckFriuWoTd7yMaQUoTutmmC1WIQlQ2iFoPkQDP-4s9Bb-HfjsjAqwOgk9V9F7W3Lt1xnNG64YtQuedSvvJriHfN_bPwL7Vw10I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>878470653</pqid></control><display><type>article</type><title>Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT</title><source>PubMed Central</source><creator>Challberg, J ; Ashcroft, L ; Lalloo, F ; Eckersley, B ; Clayton, R ; Hopwood, P ; Selby, P ; Howell, A ; Evans, D G</creator><creatorcontrib>Challberg, J ; Ashcroft, L ; Lalloo, F ; Eckersley, B ; Clayton, R ; Hopwood, P ; Selby, P ; Howell, A ; Evans, D G</creatorcontrib><description>Background:
Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision to use HRT to cover the period of oestrogen deprivation up to 50 years of age is difficult because of balancing the considerations of breast cancer risk, bone and cardiovascular health.
Methods:
We reviewed by questionnaire 289 women after BRRSPO aged ⩽48 years because of high ovarian cancer risk; 212 (73%) of women responded.
Results:
Previous HRT users (
n
=67) had significantly worse endocrine symptom scores than 67 current users (
P
=0.006). A total of 123 (58%) of women had ⩾24 months of oestrogen deprivation <50 years with 78 (37%) never taking HRT. Bone density (DXA) evaluations were available on 119 (56%) women: bone loss with a T score of ⩽−1.0 was present in 5 out of 31 (16%) women with no period of oestrogen deprivation <50 years compared with 37 out of 78 (47%) of those with ⩾24 months of oestrogen deprivation (
P
=0.03).
Interpretation:
Women undergoing BRRSPO <50 years should be counselled concerning the risks/benefits of HRT, taking into consideration the benefits on symptoms, bone health and cardiovascular health, and that the risks of breast cancer from oestrogen-only HRT appear to be relatively small.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2011.202</identifier><identifier>PMID: 21654687</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/67/1517/1709 ; 692/700/1421/2770 ; 692/700/565/1331/238 ; 692/700/565/545/546 ; Adult ; Age ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Bone ; Bone and Bones ; Bone cancer ; Bone density ; Bone loss ; BRCA1 protein ; BRCA2 protein ; Breast cancer ; Cancer ; Cancer Research ; Cardiovascular diseases ; Clinical Study ; Diseases of the osteoarticular system ; Drug Resistance ; Dual energy X-ray absorptiometry ; Epidemiology ; Estrogen Replacement Therapy ; Estrogens ; Female ; Females ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Health Status ; Humans ; Inventories ; Medical sciences ; Menopause ; Middle Aged ; Molecular Medicine ; Mutation ; Oncology ; Osteoporosis. Osteomalacia. Paget disease ; Ovarian cancer ; Ovarian carcinoma ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - prevention & control ; Ovariectomy ; Postoperative Care ; Reviews ; Risk Assessment ; Risk Factors ; Risk reduction ; Salpingostomy ; Treatment Outcome ; Tumors ; Young Adult</subject><ispartof>British journal of cancer, 2011-06, Vol.105 (1), p.22-27</ispartof><rights>The Author(s) 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 28, 2011</rights><rights>Copyright © 2011 Cancer Research UK 2011 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-6a0ce4c5234e89c9cfd98b5ad385df5dfa74be396d259027be7723b7bbdde7f83</citedby><cites>FETCH-LOGICAL-c510t-6a0ce4c5234e89c9cfd98b5ad385df5dfa74be396d259027be7723b7bbdde7f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137416/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137416/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24326942$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21654687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Challberg, J</creatorcontrib><creatorcontrib>Ashcroft, L</creatorcontrib><creatorcontrib>Lalloo, F</creatorcontrib><creatorcontrib>Eckersley, B</creatorcontrib><creatorcontrib>Clayton, R</creatorcontrib><creatorcontrib>Hopwood, P</creatorcontrib><creatorcontrib>Selby, P</creatorcontrib><creatorcontrib>Howell, A</creatorcontrib><creatorcontrib>Evans, D G</creatorcontrib><title>Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision to use HRT to cover the period of oestrogen deprivation up to 50 years of age is difficult because of balancing the considerations of breast cancer risk, bone and cardiovascular health.
Methods:
We reviewed by questionnaire 289 women after BRRSPO aged ⩽48 years because of high ovarian cancer risk; 212 (73%) of women responded.
Results:
Previous HRT users (
n
=67) had significantly worse endocrine symptom scores than 67 current users (
P
=0.006). A total of 123 (58%) of women had ⩾24 months of oestrogen deprivation <50 years with 78 (37%) never taking HRT. Bone density (DXA) evaluations were available on 119 (56%) women: bone loss with a T score of ⩽−1.0 was present in 5 out of 31 (16%) women with no period of oestrogen deprivation <50 years compared with 37 out of 78 (47%) of those with ⩾24 months of oestrogen deprivation (
P
=0.03).
Interpretation:
Women undergoing BRRSPO <50 years should be counselled concerning the risks/benefits of HRT, taking into consideration the benefits on symptoms, bone health and cardiovascular health, and that the risks of breast cancer from oestrogen-only HRT appear to be relatively small.</description><subject>692/699/67/1517/1709</subject><subject>692/700/1421/2770</subject><subject>692/700/565/1331/238</subject><subject>692/700/565/545/546</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone</subject><subject>Bone and Bones</subject><subject>Bone cancer</subject><subject>Bone density</subject><subject>Bone loss</subject><subject>BRCA1 protein</subject><subject>BRCA2 protein</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Cardiovascular diseases</subject><subject>Clinical Study</subject><subject>Diseases of the osteoarticular system</subject><subject>Drug Resistance</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Epidemiology</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens</subject><subject>Female</subject><subject>Females</subject><subject>Genes, BRCA1</subject><subject>Genes, BRCA2</subject><subject>Genetic Predisposition to Disease</subject><subject>Health Status</subject><subject>Humans</subject><subject>Inventories</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Ovarian cancer</subject><subject>Ovarian carcinoma</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - prevention & control</subject><subject>Ovariectomy</subject><subject>Postoperative Care</subject><subject>Reviews</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Risk reduction</subject><subject>Salpingostomy</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkl1rFDEUhgdR7Fq981qCIN44NV8zyXghlKJWqAhSr0OSObOb7UwyTWYs-2f8rWbYtbUiCOGEkzy855zkLYrnBJ8QzORbs7UnFBOSA31QrEjFaEkkFQ-LFcZYlLih-Kh4ktI2pw2W4nFxREld8VqKVfHzC_gw6jnpHqXdME5hSEj7FpngAW1A99MGOY9uwgAezb6FOOkr59counSFIrSzXTLjej1BXFR0P-aTUIYwbkIEmyV371Bya-86Z7Wf7munNENaSkybkAD5MKFDhfNvl0-LR53uEzw77MfF948fLs_Oy4uvnz6fnV6UtiJ4KmuNLXBbUcZBNraxXdtIU-mWyart8tKCG2BN3dKqwVQYEIIyI4xpWxCdZMfF-73uOJsBWgt-yrOoMbpBx50K2qn7N95t1Dr8UIwwwUmdBV4fBGK4zgNNanDJQt9rD2FOSkqGOSEV_z8pOG3y9yzky7_IbZijz--QIckFriuWoTd7yMaQUoTutmmC1WIQlQ2iFoPkQDP-4s9Bb-HfjsjAqwOgk9V9F7W3Lt1xnNG64YtQuedSvvJriHfN_bPwL7Vw10I</recordid><startdate>20110628</startdate><enddate>20110628</enddate><creator>Challberg, J</creator><creator>Ashcroft, L</creator><creator>Lalloo, F</creator><creator>Eckersley, B</creator><creator>Clayton, R</creator><creator>Hopwood, P</creator><creator>Selby, P</creator><creator>Howell, A</creator><creator>Evans, D G</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20110628</creationdate><title>Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT</title><author>Challberg, J ; Ashcroft, L ; Lalloo, F ; Eckersley, B ; Clayton, R ; Hopwood, P ; Selby, P ; Howell, A ; Evans, D G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-6a0ce4c5234e89c9cfd98b5ad385df5dfa74be396d259027be7723b7bbdde7f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>692/699/67/1517/1709</topic><topic>692/700/1421/2770</topic><topic>692/700/565/1331/238</topic><topic>692/700/565/545/546</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone</topic><topic>Bone and Bones</topic><topic>Bone cancer</topic><topic>Bone density</topic><topic>Bone loss</topic><topic>BRCA1 protein</topic><topic>BRCA2 protein</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Cardiovascular diseases</topic><topic>Clinical Study</topic><topic>Diseases of the osteoarticular system</topic><topic>Drug Resistance</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Epidemiology</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens</topic><topic>Female</topic><topic>Females</topic><topic>Genes, BRCA1</topic><topic>Genes, BRCA2</topic><topic>Genetic Predisposition to Disease</topic><topic>Health Status</topic><topic>Humans</topic><topic>Inventories</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Mutation</topic><topic>Oncology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Ovarian cancer</topic><topic>Ovarian carcinoma</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - prevention & control</topic><topic>Ovariectomy</topic><topic>Postoperative Care</topic><topic>Reviews</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Risk reduction</topic><topic>Salpingostomy</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Challberg, J</creatorcontrib><creatorcontrib>Ashcroft, L</creatorcontrib><creatorcontrib>Lalloo, F</creatorcontrib><creatorcontrib>Eckersley, B</creatorcontrib><creatorcontrib>Clayton, R</creatorcontrib><creatorcontrib>Hopwood, P</creatorcontrib><creatorcontrib>Selby, P</creatorcontrib><creatorcontrib>Howell, A</creatorcontrib><creatorcontrib>Evans, D G</creatorcontrib><collection>Springer Nature Open Access Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Challberg, J</au><au>Ashcroft, L</au><au>Lalloo, F</au><au>Eckersley, B</au><au>Clayton, R</au><au>Hopwood, P</au><au>Selby, P</au><au>Howell, A</au><au>Evans, D G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2011-06-28</date><risdate>2011</risdate><volume>105</volume><issue>1</issue><spage>22</spage><epage>27</epage><pages>22-27</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision to use HRT to cover the period of oestrogen deprivation up to 50 years of age is difficult because of balancing the considerations of breast cancer risk, bone and cardiovascular health.
Methods:
We reviewed by questionnaire 289 women after BRRSPO aged ⩽48 years because of high ovarian cancer risk; 212 (73%) of women responded.
Results:
Previous HRT users (
n
=67) had significantly worse endocrine symptom scores than 67 current users (
P
=0.006). A total of 123 (58%) of women had ⩾24 months of oestrogen deprivation <50 years with 78 (37%) never taking HRT. Bone density (DXA) evaluations were available on 119 (56%) women: bone loss with a T score of ⩽−1.0 was present in 5 out of 31 (16%) women with no period of oestrogen deprivation <50 years compared with 37 out of 78 (47%) of those with ⩾24 months of oestrogen deprivation (
P
=0.03).
Interpretation:
Women undergoing BRRSPO <50 years should be counselled concerning the risks/benefits of HRT, taking into consideration the benefits on symptoms, bone health and cardiovascular health, and that the risks of breast cancer from oestrogen-only HRT appear to be relatively small.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21654687</pmid><doi>10.1038/bjc.2011.202</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | British journal of cancer, 2011-06, Vol.105 (1), p.22-27 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3137416 |
| source | PubMed Central |
| subjects | 692/699/67/1517/1709 692/700/1421/2770 692/700/565/1331/238 692/700/565/545/546 Adult Age Aged Aged, 80 and over Biological and medical sciences Biomedical and Life Sciences Biomedicine Bone Bone and Bones Bone cancer Bone density Bone loss BRCA1 protein BRCA2 protein Breast cancer Cancer Cancer Research Cardiovascular diseases Clinical Study Diseases of the osteoarticular system Drug Resistance Dual energy X-ray absorptiometry Epidemiology Estrogen Replacement Therapy Estrogens Female Females Genes, BRCA1 Genes, BRCA2 Genetic Predisposition to Disease Health Status Humans Inventories Medical sciences Menopause Middle Aged Molecular Medicine Mutation Oncology Osteoporosis. Osteomalacia. Paget disease Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - prevention & control Ovariectomy Postoperative Care Reviews Risk Assessment Risk Factors Risk reduction Salpingostomy Treatment Outcome Tumors Young Adult |
| title | Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT |
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