Tumorigenesis in mice carrying a truncating Brca1 mutation

We generated mouse mutants carrying in the Brca1 locus a modification (Brca1(tr)) that eliminates the C-terminal half of the protein product and obtained results indicating that, depending on genetic background, the missing BRCT and/or other domains are dispensable for survival, but essential for tu...

Full description

Saved in:
Bibliographic Details
Published in:Genes & development 2001-05, Vol.15 (10), p.1188-1193
Main Authors: Ludwig, T, Fisher, P, Ganesan, S, Efstratiadis, A
Format: Article
Language:English
Subjects:
Animals
Blotting, Northern
Brca1 gene
BRCA1 Protein - genetics
BRCA1 Protein - metabolism
Female
Lymphoma - genetics
Lymphoma - metabolism
Lymphoma - pathology
Male
Mammary Neoplasms, Experimental - genetics
Mammary Neoplasms, Experimental - metabolism
Mammary Neoplasms, Experimental - pathology
Mice
Mice, Inbred BALB C
Mice, Mutant Strains
Mutagenesis
Neoplasms, Experimental - genetics
Neoplasms, Experimental - metabolism
Neoplasms, Experimental - pathology
Research Communication
Reverse Transcriptase Polymerase Chain Reaction
Sarcoma, Experimental - genetics
Sarcoma, Experimental - metabolism
Sarcoma, Experimental - pathology
Sequence Deletion
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We generated mouse mutants carrying in the Brca1 locus a modification (Brca1(tr)) that eliminates the C-terminal half of the protein product and obtained results indicating that, depending on genetic background, the missing BRCT and/or other domains are dispensable for survival, but essential for tumor suppression. Most of the apparently hypomorphic Brca1(tr/tr) mutants developed various tumors. Lymphomas were detected at all ages, whereas sarcomas and carcinomas, including breast cancer, appeared after a long latency. The mammary tumors showed striking variability in histopathological patterns suggesting stochastic engagement of tumorigenic pathways in their progression, to which the Brca1(tr/tr) mutation was apparently a late participant.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.879201