Pineal function: Impact of microarray analysis

Microarray analysis has provided a new understanding of pineal function by identifying genes that are highly expressed in this tissue relative to other tissues and also by identifying over 600 genes that are expressed on a 24-h schedule. This effort has highlighted surprising similarity to the retin...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2010-01, Vol.314 (2), p.170-183
Main Authors: Klein, David C., Bailey, Michael J., Carter, David A., Kim, Jong-so, Shi, Qiong, Ho, Anthony K., Chik, Constance L., Gaildrat, Pascaline, Morin, Fabrice, Ganguly, Surajit, Rath, Martin F., Møller, Morten, Sugden, David, Rangel, Zoila G., Munson, Peter J., Weller, Joan L., Coon, Steven L.
Format: Article
Language:English
Subjects:
Animals
Biochemistry, Molecular Biology
Circadian Rhythm - genetics
Circadian rhythms
Cyclic AMP signaling
Humans
Immune response
Inflammation
Life Sciences
MAP kinase
Melatonin
Melatonin - physiology
Microarray
Neurons - physiology
Oligonucleotide Array Sequence Analysis
Pineal
Pineal Gland - physiology
RNA splicing
Signal Transduction - genetics
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Summary:Microarray analysis has provided a new understanding of pineal function by identifying genes that are highly expressed in this tissue relative to other tissues and also by identifying over 600 genes that are expressed on a 24-h schedule. This effort has highlighted surprising similarity to the retina and has provided reason to explore new avenues of study including intracellular signaling, signal transduction, transcriptional cascades, thyroid/retinoic acid hormone signaling, metal biology, RNA splicing, and the role the pineal gland plays in the immune/inflammation response. The new foundation that microarray analysis has provided will broadly support future research on pineal function.
ISSN:0303-7207
1872-8057
1872-8057
0303-7207
DOI:10.1016/j.mce.2009.07.010