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Temporal Trends in Presentation for Outpatient HIV Medical Care 2000–2010: Implications for Short-term Mortality
Background Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications. Objective To assess temporal trends in late presentation for o...
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Published in: | Journal of general internal medicine : JGIM 2011-07, Vol.26 (7), p.745-750, Article 745 |
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creator | Seal, Paula S. Jackson, David A. Chamot, Eric Willig, James H. Nevin, Christa R. Allison, Jeroan J. Raper, James L. Kempf, Mirjam C. Schumacher, Joseph E. Saag, Michael S. Mugavero, Michael J. |
description | Background
Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications.
Objective
To assess temporal trends in late presentation for outpatient HIV medial care as measured by CD4 count |
doi_str_mv | 10.1007/s11606-011-1693-x |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3138583</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2375974721</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-60cdeb9ab012b4fc05346ac88e13b8367561621d7d65176c99a32fb319db658b3</originalsourceid><addsrcrecordid>eNp9UctuFDEQtBCILIEP4IIsJI6TuP0eDkhoRchKiYLEwtXyeDyJo3lhz6Lkln_gD_mSeDNLAkhwst1dVV3tQuglkAMgRB0mAElkQQAKkCUrrh6hBQgqCuCleowWRGteaMX4HnqW0iUhwCjVT9EeBS4FI7BAce27cYi2xevo-zrh0ONP0SffT3YKQ4-bIeKzzTTmV67h49VXfOrr4DJjaaPHlBDy8-YHJUDe4lU3trm1JaY75ueLIU7F5GOHT_PNtmG6fo6eNLZN_sXu3Edfjj6sl8fFydnH1fL9SeG4lFMhiat9VdqKAK1444hgXFqntQdWaSaVkCAp1KqWApR0ZWkZbSoGZV1JoSu2j97NuuOm6nztsv28pxlj6Gy8NoMN5s9OHy7M-fDdMGBaaJYFXu8E4vBt49NkLodN7LNnoxWUqlS8zCCYQS4OKUXf3A8AYrYpmTklk1My25TMVea8-t3ZPeNXLBnwZgewKf90E23vQnrAcSaFgK1D9ddwF-bc8kKh_a8FOjNTFu3PfXzY7d-kW7xhvXw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>871979749</pqid></control><display><type>article</type><title>Temporal Trends in Presentation for Outpatient HIV Medical Care 2000–2010: Implications for Short-term Mortality</title><source>Open Access: PubMed Central</source><source>Springer Link</source><creator>Seal, Paula S. ; Jackson, David A. ; Chamot, Eric ; Willig, James H. ; Nevin, Christa R. ; Allison, Jeroan J. ; Raper, James L. ; Kempf, Mirjam C. ; Schumacher, Joseph E. ; Saag, Michael S. ; Mugavero, Michael J.</creator><creatorcontrib>Seal, Paula S. ; Jackson, David A. ; Chamot, Eric ; Willig, James H. ; Nevin, Christa R. ; Allison, Jeroan J. ; Raper, James L. ; Kempf, Mirjam C. ; Schumacher, Joseph E. ; Saag, Michael S. ; Mugavero, Michael J.</creatorcontrib><description>Background
Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications.
Objective
To assess temporal trends in late presentation for outpatient HIV medial care as measured by CD4 count <200 cells/mm
3
and the implications on short-term (1-year) mortality.
Design
We conducted a cohort study nested in a prospective HIV clinical cohort including patients establishing initial outpatient HIV treatment between 2000–2010. Time series regression analysis evaluated temporal trends in late presentation for care measured by the proportion of patients with a CD4 count <200 cells/mm
3
or an opportunistic infection at enrollment, and also evaluated trends in short-term mortality.
Participants
Patients establishing initial outpatient HIV treatment between 2000–2010 at an academic HIV clinic.
Main Measures
The proportion of patients with a CD4 count <200 cells/mm
3
or an opportunistic infection at initial presentation and short-term (1-year) mortality following clinic enrollment.
Key Results
Among 1121 patients, 41% had an initial CD4 count <200 cells/mm
3
, 25% had an opportunistic infection and 2.4% died within 1-year of their initial visit. Time series regression analysis demonstrated significant reductions in late presentation for HIV care and decreases in short-term mortality with temporal improvement preceding updated CDC HIV testing recommendations.
Conclusion
We observed a significant decline in the number of patients presenting for outpatient HIV care with advanced disease, particularly in 2006–2010. A significant trend in improved short-term survival among patients establishing HIV care was also observed, likely related to more timely presentation for outpatient care in more recent years.</description><identifier>ISSN: 0884-8734</identifier><identifier>EISSN: 1525-1497</identifier><identifier>DOI: 10.1007/s11606-011-1693-x</identifier><identifier>PMID: 21465301</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; CD4 Lymphocyte Count ; Cohort Studies ; Delivery of Health Care - trends ; Epidemiology ; Female ; General aspects ; Health Policy ; HIV ; HIV Infections - diagnosis ; HIV Infections - mortality ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Internal Medicine ; Male ; Medical diagnosis ; Medical sciences ; Medical tests ; Medicine ; Medicine & Public Health ; Mortality ; Original Research ; Outpatient care facilities ; Outpatients - statistics & numerical data ; Patient Acceptance of Health Care ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Southeastern United States ; Survival Rate ; Time Factors ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Journal of general internal medicine : JGIM, 2011-07, Vol.26 (7), p.745-750, Article 745</ispartof><rights>Society of General Internal Medicine 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-60cdeb9ab012b4fc05346ac88e13b8367561621d7d65176c99a32fb319db658b3</citedby><cites>FETCH-LOGICAL-c466t-60cdeb9ab012b4fc05346ac88e13b8367561621d7d65176c99a32fb319db658b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138583/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138583/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24365513$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21465301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seal, Paula S.</creatorcontrib><creatorcontrib>Jackson, David A.</creatorcontrib><creatorcontrib>Chamot, Eric</creatorcontrib><creatorcontrib>Willig, James H.</creatorcontrib><creatorcontrib>Nevin, Christa R.</creatorcontrib><creatorcontrib>Allison, Jeroan J.</creatorcontrib><creatorcontrib>Raper, James L.</creatorcontrib><creatorcontrib>Kempf, Mirjam C.</creatorcontrib><creatorcontrib>Schumacher, Joseph E.</creatorcontrib><creatorcontrib>Saag, Michael S.</creatorcontrib><creatorcontrib>Mugavero, Michael J.</creatorcontrib><title>Temporal Trends in Presentation for Outpatient HIV Medical Care 2000–2010: Implications for Short-term Mortality</title><title>Journal of general internal medicine : JGIM</title><addtitle>J GEN INTERN MED</addtitle><addtitle>J Gen Intern Med</addtitle><description>Background
Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications.
Objective
To assess temporal trends in late presentation for outpatient HIV medial care as measured by CD4 count <200 cells/mm
3
and the implications on short-term (1-year) mortality.
Design
We conducted a cohort study nested in a prospective HIV clinical cohort including patients establishing initial outpatient HIV treatment between 2000–2010. Time series regression analysis evaluated temporal trends in late presentation for care measured by the proportion of patients with a CD4 count <200 cells/mm
3
or an opportunistic infection at enrollment, and also evaluated trends in short-term mortality.
Participants
Patients establishing initial outpatient HIV treatment between 2000–2010 at an academic HIV clinic.
Main Measures
The proportion of patients with a CD4 count <200 cells/mm
3
or an opportunistic infection at initial presentation and short-term (1-year) mortality following clinic enrollment.
Key Results
Among 1121 patients, 41% had an initial CD4 count <200 cells/mm
3
, 25% had an opportunistic infection and 2.4% died within 1-year of their initial visit. Time series regression analysis demonstrated significant reductions in late presentation for HIV care and decreases in short-term mortality with temporal improvement preceding updated CDC HIV testing recommendations.
Conclusion
We observed a significant decline in the number of patients presenting for outpatient HIV care with advanced disease, particularly in 2006–2010. A significant trend in improved short-term survival among patients establishing HIV care was also observed, likely related to more timely presentation for outpatient care in more recent years.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Cohort Studies</subject><subject>Delivery of Health Care - trends</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Health Policy</subject><subject>HIV</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - mortality</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Medical tests</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Original Research</subject><subject>Outpatient care facilities</subject><subject>Outpatients - statistics & numerical data</subject><subject>Patient Acceptance of Health Care</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Southeastern United States</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0884-8734</issn><issn>1525-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9UctuFDEQtBCILIEP4IIsJI6TuP0eDkhoRchKiYLEwtXyeDyJo3lhz6Lkln_gD_mSeDNLAkhwst1dVV3tQuglkAMgRB0mAElkQQAKkCUrrh6hBQgqCuCleowWRGteaMX4HnqW0iUhwCjVT9EeBS4FI7BAce27cYi2xevo-zrh0ONP0SffT3YKQ4-bIeKzzTTmV67h49VXfOrr4DJjaaPHlBDy8-YHJUDe4lU3trm1JaY75ueLIU7F5GOHT_PNtmG6fo6eNLZN_sXu3Edfjj6sl8fFydnH1fL9SeG4lFMhiat9VdqKAK1444hgXFqntQdWaSaVkCAp1KqWApR0ZWkZbSoGZV1JoSu2j97NuuOm6nztsv28pxlj6Gy8NoMN5s9OHy7M-fDdMGBaaJYFXu8E4vBt49NkLodN7LNnoxWUqlS8zCCYQS4OKUXf3A8AYrYpmTklk1My25TMVea8-t3ZPeNXLBnwZgewKf90E23vQnrAcSaFgK1D9ddwF-bc8kKh_a8FOjNTFu3PfXzY7d-kW7xhvXw</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Seal, Paula S.</creator><creator>Jackson, David A.</creator><creator>Chamot, Eric</creator><creator>Willig, James H.</creator><creator>Nevin, Christa R.</creator><creator>Allison, Jeroan J.</creator><creator>Raper, James L.</creator><creator>Kempf, Mirjam C.</creator><creator>Schumacher, Joseph E.</creator><creator>Saag, Michael S.</creator><creator>Mugavero, Michael J.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20110701</creationdate><title>Temporal Trends in Presentation for Outpatient HIV Medical Care 2000–2010: Implications for Short-term Mortality</title><author>Seal, Paula S. ; Jackson, David A. ; Chamot, Eric ; Willig, James H. ; Nevin, Christa R. ; Allison, Jeroan J. ; Raper, James L. ; Kempf, Mirjam C. ; Schumacher, Joseph E. ; Saag, Michael S. ; Mugavero, Michael J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-60cdeb9ab012b4fc05346ac88e13b8367561621d7d65176c99a32fb319db658b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>Cohort Studies</topic><topic>Delivery of Health Care - trends</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Health Policy</topic><topic>HIV</topic><topic>HIV Infections - diagnosis</topic><topic>HIV Infections - mortality</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Medical tests</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Original Research</topic><topic>Outpatient care facilities</topic><topic>Outpatients - statistics & numerical data</topic><topic>Patient Acceptance of Health Care</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Southeastern United States</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seal, Paula S.</creatorcontrib><creatorcontrib>Jackson, David A.</creatorcontrib><creatorcontrib>Chamot, Eric</creatorcontrib><creatorcontrib>Willig, James H.</creatorcontrib><creatorcontrib>Nevin, Christa R.</creatorcontrib><creatorcontrib>Allison, Jeroan J.</creatorcontrib><creatorcontrib>Raper, James L.</creatorcontrib><creatorcontrib>Kempf, Mirjam C.</creatorcontrib><creatorcontrib>Schumacher, Joseph E.</creatorcontrib><creatorcontrib>Saag, Michael S.</creatorcontrib><creatorcontrib>Mugavero, Michael J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of general internal medicine : JGIM</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seal, Paula S.</au><au>Jackson, David A.</au><au>Chamot, Eric</au><au>Willig, James H.</au><au>Nevin, Christa R.</au><au>Allison, Jeroan J.</au><au>Raper, James L.</au><au>Kempf, Mirjam C.</au><au>Schumacher, Joseph E.</au><au>Saag, Michael S.</au><au>Mugavero, Michael J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal Trends in Presentation for Outpatient HIV Medical Care 2000–2010: Implications for Short-term Mortality</atitle><jtitle>Journal of general internal medicine : JGIM</jtitle><stitle>J GEN INTERN MED</stitle><addtitle>J Gen Intern Med</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>26</volume><issue>7</issue><spage>745</spage><epage>750</epage><pages>745-750</pages><artnum>745</artnum><issn>0884-8734</issn><eissn>1525-1497</eissn><abstract>Background
Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications.
Objective
To assess temporal trends in late presentation for outpatient HIV medial care as measured by CD4 count <200 cells/mm
3
and the implications on short-term (1-year) mortality.
Design
We conducted a cohort study nested in a prospective HIV clinical cohort including patients establishing initial outpatient HIV treatment between 2000–2010. Time series regression analysis evaluated temporal trends in late presentation for care measured by the proportion of patients with a CD4 count <200 cells/mm
3
or an opportunistic infection at enrollment, and also evaluated trends in short-term mortality.
Participants
Patients establishing initial outpatient HIV treatment between 2000–2010 at an academic HIV clinic.
Main Measures
The proportion of patients with a CD4 count <200 cells/mm
3
or an opportunistic infection at initial presentation and short-term (1-year) mortality following clinic enrollment.
Key Results
Among 1121 patients, 41% had an initial CD4 count <200 cells/mm
3
, 25% had an opportunistic infection and 2.4% died within 1-year of their initial visit. Time series regression analysis demonstrated significant reductions in late presentation for HIV care and decreases in short-term mortality with temporal improvement preceding updated CDC HIV testing recommendations.
Conclusion
We observed a significant decline in the number of patients presenting for outpatient HIV care with advanced disease, particularly in 2006–2010. A significant trend in improved short-term survival among patients establishing HIV care was also observed, likely related to more timely presentation for outpatient care in more recent years.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21465301</pmid><doi>10.1007/s11606-011-1693-x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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source | Open Access: PubMed Central; Springer Link |
subjects | Adolescent Adult Biological and medical sciences CD4 Lymphocyte Count Cohort Studies Delivery of Health Care - trends Epidemiology Female General aspects Health Policy HIV HIV Infections - diagnosis HIV Infections - mortality Human immunodeficiency virus Human viral diseases Humans Infectious diseases Internal Medicine Male Medical diagnosis Medical sciences Medical tests Medicine Medicine & Public Health Mortality Original Research Outpatient care facilities Outpatients - statistics & numerical data Patient Acceptance of Health Care Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Southeastern United States Survival Rate Time Factors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
title | Temporal Trends in Presentation for Outpatient HIV Medical Care 2000–2010: Implications for Short-term Mortality |
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