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Temporal Trends in Presentation for Outpatient HIV Medical Care 2000–2010: Implications for Short-term Mortality

Background Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications. Objective To assess temporal trends in late presentation for o...

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Published in:Journal of general internal medicine : JGIM 2011-07, Vol.26 (7), p.745-750, Article 745
Main Authors: Seal, Paula S., Jackson, David A., Chamot, Eric, Willig, James H., Nevin, Christa R., Allison, Jeroan J., Raper, James L., Kempf, Mirjam C., Schumacher, Joseph E., Saag, Michael S., Mugavero, Michael J.
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Jackson, David A.
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Schumacher, Joseph E.
Saag, Michael S.
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description Background Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications. Objective To assess temporal trends in late presentation for outpatient HIV medial care as measured by CD4 count
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More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications. Objective To assess temporal trends in late presentation for outpatient HIV medial care as measured by CD4 count &lt;200 cells/mm 3 and the implications on short-term (1-year) mortality. Design We conducted a cohort study nested in a prospective HIV clinical cohort including patients establishing initial outpatient HIV treatment between 2000–2010. Time series regression analysis evaluated temporal trends in late presentation for care measured by the proportion of patients with a CD4 count &lt;200 cells/mm 3 or an opportunistic infection at enrollment, and also evaluated trends in short-term mortality. Participants Patients establishing initial outpatient HIV treatment between 2000–2010 at an academic HIV clinic. Main Measures The proportion of patients with a CD4 count &lt;200 cells/mm 3 or an opportunistic infection at initial presentation and short-term (1-year) mortality following clinic enrollment. Key Results Among 1121 patients, 41% had an initial CD4 count &lt;200 cells/mm 3 , 25% had an opportunistic infection and 2.4% died within 1-year of their initial visit. Time series regression analysis demonstrated significant reductions in late presentation for HIV care and decreases in short-term mortality with temporal improvement preceding updated CDC HIV testing recommendations. Conclusion We observed a significant decline in the number of patients presenting for outpatient HIV care with advanced disease, particularly in 2006–2010. A significant trend in improved short-term survival among patients establishing HIV care was also observed, likely related to more timely presentation for outpatient care in more recent years.</description><identifier>ISSN: 0884-8734</identifier><identifier>EISSN: 1525-1497</identifier><identifier>DOI: 10.1007/s11606-011-1693-x</identifier><identifier>PMID: 21465301</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; CD4 Lymphocyte Count ; Cohort Studies ; Delivery of Health Care - trends ; Epidemiology ; Female ; General aspects ; Health Policy ; HIV ; HIV Infections - diagnosis ; HIV Infections - mortality ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Internal Medicine ; Male ; Medical diagnosis ; Medical sciences ; Medical tests ; Medicine ; Medicine &amp; Public Health ; Mortality ; Original Research ; Outpatient care facilities ; Outpatients - statistics &amp; numerical data ; Patient Acceptance of Health Care ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Southeastern United States ; Survival Rate ; Time Factors ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Journal of general internal medicine : JGIM, 2011-07, Vol.26 (7), p.745-750, Article 745</ispartof><rights>Society of General Internal Medicine 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-60cdeb9ab012b4fc05346ac88e13b8367561621d7d65176c99a32fb319db658b3</citedby><cites>FETCH-LOGICAL-c466t-60cdeb9ab012b4fc05346ac88e13b8367561621d7d65176c99a32fb319db658b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138583/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138583/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=24365513$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21465301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seal, Paula S.</creatorcontrib><creatorcontrib>Jackson, David A.</creatorcontrib><creatorcontrib>Chamot, Eric</creatorcontrib><creatorcontrib>Willig, James H.</creatorcontrib><creatorcontrib>Nevin, Christa R.</creatorcontrib><creatorcontrib>Allison, Jeroan J.</creatorcontrib><creatorcontrib>Raper, James L.</creatorcontrib><creatorcontrib>Kempf, Mirjam C.</creatorcontrib><creatorcontrib>Schumacher, Joseph E.</creatorcontrib><creatorcontrib>Saag, Michael S.</creatorcontrib><creatorcontrib>Mugavero, Michael J.</creatorcontrib><title>Temporal Trends in Presentation for Outpatient HIV Medical Care 2000–2010: Implications for Short-term Mortality</title><title>Journal of general internal medicine : JGIM</title><addtitle>J GEN INTERN MED</addtitle><addtitle>J Gen Intern Med</addtitle><description>Background Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications. Objective To assess temporal trends in late presentation for outpatient HIV medial care as measured by CD4 count &lt;200 cells/mm 3 and the implications on short-term (1-year) mortality. Design We conducted a cohort study nested in a prospective HIV clinical cohort including patients establishing initial outpatient HIV treatment between 2000–2010. Time series regression analysis evaluated temporal trends in late presentation for care measured by the proportion of patients with a CD4 count &lt;200 cells/mm 3 or an opportunistic infection at enrollment, and also evaluated trends in short-term mortality. Participants Patients establishing initial outpatient HIV treatment between 2000–2010 at an academic HIV clinic. Main Measures The proportion of patients with a CD4 count &lt;200 cells/mm 3 or an opportunistic infection at initial presentation and short-term (1-year) mortality following clinic enrollment. Key Results Among 1121 patients, 41% had an initial CD4 count &lt;200 cells/mm 3 , 25% had an opportunistic infection and 2.4% died within 1-year of their initial visit. Time series regression analysis demonstrated significant reductions in late presentation for HIV care and decreases in short-term mortality with temporal improvement preceding updated CDC HIV testing recommendations. Conclusion We observed a significant decline in the number of patients presenting for outpatient HIV care with advanced disease, particularly in 2006–2010. A significant trend in improved short-term survival among patients establishing HIV care was also observed, likely related to more timely presentation for outpatient care in more recent years.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Cohort Studies</subject><subject>Delivery of Health Care - trends</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Health Policy</subject><subject>HIV</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - mortality</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Medical tests</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Mortality</subject><subject>Original Research</subject><subject>Outpatient care facilities</subject><subject>Outpatients - statistics &amp; numerical data</subject><subject>Patient Acceptance of Health Care</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Southeastern United States</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications. Objective To assess temporal trends in late presentation for outpatient HIV medial care as measured by CD4 count &lt;200 cells/mm 3 and the implications on short-term (1-year) mortality. Design We conducted a cohort study nested in a prospective HIV clinical cohort including patients establishing initial outpatient HIV treatment between 2000–2010. Time series regression analysis evaluated temporal trends in late presentation for care measured by the proportion of patients with a CD4 count &lt;200 cells/mm 3 or an opportunistic infection at enrollment, and also evaluated trends in short-term mortality. Participants Patients establishing initial outpatient HIV treatment between 2000–2010 at an academic HIV clinic. Main Measures The proportion of patients with a CD4 count &lt;200 cells/mm 3 or an opportunistic infection at initial presentation and short-term (1-year) mortality following clinic enrollment. Key Results Among 1121 patients, 41% had an initial CD4 count &lt;200 cells/mm 3 , 25% had an opportunistic infection and 2.4% died within 1-year of their initial visit. Time series regression analysis demonstrated significant reductions in late presentation for HIV care and decreases in short-term mortality with temporal improvement preceding updated CDC HIV testing recommendations. Conclusion We observed a significant decline in the number of patients presenting for outpatient HIV care with advanced disease, particularly in 2006–2010. A significant trend in improved short-term survival among patients establishing HIV care was also observed, likely related to more timely presentation for outpatient care in more recent years.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21465301</pmid><doi>10.1007/s11606-011-1693-x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Biological and medical sciences
CD4 Lymphocyte Count
Cohort Studies
Delivery of Health Care - trends
Epidemiology
Female
General aspects
Health Policy
HIV
HIV Infections - diagnosis
HIV Infections - mortality
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Internal Medicine
Male
Medical diagnosis
Medical sciences
Medical tests
Medicine
Medicine & Public Health
Mortality
Original Research
Outpatient care facilities
Outpatients - statistics & numerical data
Patient Acceptance of Health Care
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Southeastern United States
Survival Rate
Time Factors
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
title Temporal Trends in Presentation for Outpatient HIV Medical Care 2000–2010: Implications for Short-term Mortality
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