Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics

Infection and inflammation are associated with downregulation of hepatic and extrahepatic cytochrome P450s as well as other drug‐metabolizing enzymes and transporters. We review the genesis of inflammatory reactions and discuss the relevance of the inflammation‐related regulation of cytochrome P450...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2009-04, Vol.85 (4), p.434-438
Main Author: Morgan, ET
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Communicable Diseases - enzymology
Communicable Diseases - pathology
Cytochrome P-450 Enzyme System - metabolism
Down-Regulation - physiology
Drug Interactions - physiology
Humans
Inflammation - metabolism
Inflammation Mediators - physiology
Medical sciences
Pharmaceutical Preparations - metabolism
Pharmacology. Drug treatments
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Summary:Infection and inflammation are associated with downregulation of hepatic and extrahepatic cytochrome P450s as well as other drug‐metabolizing enzymes and transporters. We review the genesis of inflammatory reactions and discuss the relevance of the inflammation‐related regulation of cytochrome P450 enzymes to clinical drug–disease and drug–drug interactions. An understanding of the enzyme specificity and mechanisms of regulation will allow us to make better decisions about adjusting drug dosage regimens when a patient's inflammatory status changes. Clinical Pharmacology & Therapeutics (2009); 85, 4, 434–438 doi:10.1038/clpt.2008.302
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2008.302