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Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics
Infection and inflammation are associated with downregulation of hepatic and extrahepatic cytochrome P450s as well as other drug‐metabolizing enzymes and transporters. We review the genesis of inflammatory reactions and discuss the relevance of the inflammation‐related regulation of cytochrome P450...
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| Published in: | Clinical pharmacology and therapeutics 2009-04, Vol.85 (4), p.434-438 |
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| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c5312-31b7b1d506f151c3de225805fad9e9b7cd954b615bc2ba67c3aeb479a1ae38823 |
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| cites | cdi_FETCH-LOGICAL-c5312-31b7b1d506f151c3de225805fad9e9b7cd954b615bc2ba67c3aeb479a1ae38823 |
| container_end_page | 438 |
| container_issue | 4 |
| container_start_page | 434 |
| container_title | Clinical pharmacology and therapeutics |
| container_volume | 85 |
| creator | Morgan, ET |
| description | Infection and inflammation are associated with downregulation of hepatic and extrahepatic cytochrome P450s as well as other drug‐metabolizing enzymes and transporters. We review the genesis of inflammatory reactions and discuss the relevance of the inflammation‐related regulation of cytochrome P450 enzymes to clinical drug–disease and drug–drug interactions. An understanding of the enzyme specificity and mechanisms of regulation will allow us to make better decisions about adjusting drug dosage regimens when a patient's inflammatory status changes.
Clinical Pharmacology & Therapeutics (2009); 85, 4, 434–438 doi:10.1038/clpt.2008.302 |
| doi_str_mv | 10.1038/clpt.2008.302 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0009-9236 |
| ispartof | Clinical pharmacology and therapeutics, 2009-04, Vol.85 (4), p.434-438 |
| issn | 0009-9236 1532-6535 |
| language | eng |
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| source | Wiley |
| subjects | Animals Biological and medical sciences Communicable Diseases - enzymology Communicable Diseases - pathology Cytochrome P-450 Enzyme System - metabolism Down-Regulation - physiology Drug Interactions - physiology Humans Inflammation - metabolism Inflammation Mediators - physiology Medical sciences Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments |
| title | Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics |
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