Biologic and Plastic Effects of Experimental Traumatic Brain Injury Treatment Paradigms and Their Relevance to Clinical Rehabilitation

Neuroplastic changes, whether induced by traumatic brain injury (TBI) or therapeutic interventions, alter neurobehavioral outcome. Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and ho...

Full description

Saved in:
Bibliographic Details
Published in:PM & R 2011-06, Vol.3 (6), p.S18-S27
Main Authors: Garcia, Alexandra N., BS, Shah, Mansi A., BS, Dixon, C. Edward, PhD, Wagner, Amy K., MD, Kline, Anthony E., PhD
Format: Article
Language:English
Subjects:
Animals
Brain Injuries - metabolism
Brain Injuries - physiopathology
Brain Injuries - rehabilitation
Disease Models, Animal
Neuronal Plasticity - physiology
Neurotransmitter Agents - metabolism
Physical Medicine and Rehabilitation
Physical Therapy Modalities
Recovery of Function
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neuroplastic changes, whether induced by traumatic brain injury (TBI) or therapeutic interventions, alter neurobehavioral outcome. Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and how such changes affect function.
ISSN:1934-1482
1934-1563
DOI:10.1016/j.pmrj.2011.03.017