Is sperm dna damage associated with IVF embryo quality? A systematic review

Purpose Sperm DNA damage is common amongst infertile men and may adversely impact natural reproduction, IUI-assisted reproduction and to a lesser degree IVF pregnancy. The objective of this study was to examine the influence of sperm DNA damage on embryo quality and/or development at IVF and ICSI. M...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2011-05, Vol.28 (5), p.391-397
Main Authors: Zini, Armand, Jamal, Wael, Cowan, Lisa, Al-Hathal, Naif
Format: Article
Language:English
Subjects:
DNA Damage
Embryo, Mammalian - cytology
Embryo, Mammalian - metabolism
Embryonic Development
Embryos
Fertility
Fertilization in Vitro
Gamete Biology
Gynecology
Human Genetics
Humans
In vitro fertilization
Infertility
Male
Medicine
Medicine & Public Health
Pregnancy
Reproductive Medicine
Reproductive technologies
Sperm
Sperm Injections, Intracytoplasmic
Spermatozoa - metabolism
Systematic review
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Summary:Purpose Sperm DNA damage is common amongst infertile men and may adversely impact natural reproduction, IUI-assisted reproduction and to a lesser degree IVF pregnancy. The objective of this study was to examine the influence of sperm DNA damage on embryo quality and/or development at IVF and ICSI. Methods We conducted a systematic review of studies that evaluated sperm DNA damage and embryo development and/or quality after IVF and/or ICSI. Results We identified 28 studies (8 IVF, 12 ICSI and 8 mixed IVF-ICSI studies) that evaluated the relationship between sperm DNA damage and embryo quality. These 28 studies evaluated 3226 treatment cycles (1033 IVF and 873 ICSI, 1320 mixed IVF-ICSI cycles) and demonstrated highly variable characteristics. In 11 of the 28 studies (1/8 IVF, 5/12 ICSI and 5/8 mixed IVF-ICSI studies), sperm DNA damage was associated with poor embryo quality and/or development, whereas the remaining 17 studies showed no relationship between sperm DNA damage and embryo quality and/or development. Conclusions This systematic review indicates that the evaluable studies are heterogeneous and that overall, there is no consistent relationship between sperm DNA damage and embryo quality and/or development. The data also suggest that the influence of sperm DNA damage on embryo quality/development may be more significant in ICSI compared to IVF cycles.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-011-9544-6