NLRP3 inflammasomes link inflammation and metabolic disease

A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, athero...

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Bibliographic Details
Published in:Trends in immunology 2011-08, Vol.32 (8), p.373-379
Main Authors: De Nardo, Dominic, Latz, Eicke
Format: Article
Language:English
Subjects:
Allergy and Immunology
Alzheimer's disease
Animals
Aqueous solutions
Atherosclerosis
Carrier Proteins - immunology
Cholesterol
Crystals
Cytokines
Heart attacks
Humans
Immune system
Immunotherapy - trends
Inflammasomes - immunology
Inflammation
Interleukin-18 - immunology
Interleukin-1beta - immunology
Metabolic Diseases - drug therapy
Metabolic Diseases - immunology
Metabolic disorders
Molecular Targeted Therapy
Molecular weight
NLR Family, Pyrin Domain-Containing 3 Protein
Proteins
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Summary:A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2011.05.004