Cross sensitivity between ciprofloxacin and levofloxacin for an immediate hypersensitivity reaction

Seven years old male child (24 kg weight) diagnosed as a case of sub acute appendicitis treated with ciprofloxacin, immediately developed multiple erythmatous papules. Reaction subsided after withholding ciprofloxacin and treatment with dexamethasone and chlorpheneramine maleate. It was developed ag...

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Bibliographic Details
Published in:Journal of pharmacology & pharmacotherapeutics 2011-07, Vol.2 (3), p.187-188
Main Authors: Anovadiya, Ashish P, Barvaliya, Manish J, Patel, Tejas K, Tripathi, C B
Format: Article
Language:English
Subjects:
Allergies
Case Report
Ciprofloxacin
Complications and side effects
Dosage and administration
Drug allergy
Drug therapy
Levofloxacin
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Summary:Seven years old male child (24 kg weight) diagnosed as a case of sub acute appendicitis treated with ciprofloxacin, immediately developed multiple erythmatous papules. Reaction subsided after withholding ciprofloxacin and treatment with dexamethasone and chlorpheneramine maleate. It was developed again when treated with levofloxacin and subsided after withdrawal. IgE binding at 7(th) position of core structure of fluoroquinolones likely to be the mechanism. As all the fluoroquinolones have similar core structure, hypersensitivity to one may have cross sensitivity to other fluoroquinolones. It is advisable to avoid other fluoroquinolones and switch over to other group of antibiotics when hypersensitivity to one occurs.
ISSN:0976-500X
0976-5018
DOI:10.4103/0976-500X.83285