Identification of a novel mechanism of regulation of Ah (dioxin) receptor function

Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3, 7,8-tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expressi...

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Bibliographic Details
Published in:Genes & development 1999-01, Vol.13 (1), p.20-25
Main Authors: Mimura, J, Ema, M, Sogawa, K, Fujii-Kuriyama, Y
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Aryl Hydrocarbon Receptor Nuclear Translocator
Basic Helix-Loop-Helix Transcription Factors
Cloning, Molecular
Dimerization
DNA-Binding Proteins
Gene Expression Regulation - genetics
Helix-Loop-Helix Motifs - genetics
Mice
Molecular Sequence Data
Polychlorinated Dibenzodioxins - metabolism
Promoter Regions, Genetic - genetics
Protein Binding - genetics
Receptors, Aryl Hydrocarbon - metabolism
Recombinant Fusion Proteins - genetics
Repressor Proteins - chemistry
Repressor Proteins - genetics
Research Communication
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Transcription Factors - genetics
Transcription Factors - metabolism
Transcriptional Activation - genetics
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Summary:Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3, 7,8-tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.13.1.20