Swine influenza virus antibodies in humans, western Europe, 2009

Serologic studies for swine influenza viruses (SIVs) in humans with occupational exposure to swine have been reported from the Americas but not from Europe. We compared levels of neutralizing antibodies against 3 influenza viruses--pandemic (H1N1) 2009, an avian-like enzootic subtype H1N1 SIV, and a...

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Bibliographic Details
Published in:Emerging infectious diseases 2011-03, Vol.17 (3), p.403-411
Main Authors: Gerloff, Nancy A, Kremer, Jacques R, Charpentier, Emilie, Sausy, Aurélie, Olinger, Christophe M, Weicherding, Pierre, Schuh, John, Van Reeth, Kristien, Muller, Claude P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Care and treatment
Control
Cross Reactions
Europe - epidemiology
Female
Humans
Influenza A virus - immunology
Influenza A Virus, H1N1 Subtype - immunology
Influenza Vaccines - immunology
Influenza viruses
Influenza, Human - immunology
Influenza, Human - virology
Luxembourg
Male
Middle Aged
Observations
Pandemics
Properties
Seasons
Swine
Swine Diseases - immunology
Swine Diseases - virology
Swine influenza
Viral antibodies
Young Adult
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Summary:Serologic studies for swine influenza viruses (SIVs) in humans with occupational exposure to swine have been reported from the Americas but not from Europe. We compared levels of neutralizing antibodies against 3 influenza viruses--pandemic (H1N1) 2009, an avian-like enzootic subtype H1N1 SIV, and a 2007-08 seasonal subtype H1N1--in 211 persons with swine contact and 224 matched controls in Luxembourg. Persons whose profession involved contact with swine had more neutralizing antibodies against SIV and pandemic (H1N1) 2009 virus than did the controls. Controls also had antibodies against these viruses although exposure to them was unlikely. Antibodies against SIV and pandemic (H1N1) 2009 virus correlated with each other but not with seasonal subtype H1N1 virus. Sequential exposure to variants of seasonal influenza (H1N1) viruses may have increased chances for serologic cross-reactivity with antigenically distinct viruses. Further studies are needed to determine the extent to which serologic responses correlate with infection.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1703100581