Normal Exercise Blood Pressure Response in African-American Women with Parental History of Hypertension

Genetic and environmental hypotheses may explain why normotensive persons at high risk of developing hypertension often exhibit greater cardiovascular reactivity to stressors than those at low risk. Pearson’s correlation was used to evaluate reproducibility and independent t test to compare the card...

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Bibliographic Details
Published in:The American journal of the medical sciences 2004-08, Vol.328 (2), p.78-83
Main Authors: Bond, Vernon, Davis, Gwendolyn C., Millis, Richard M., Williams, Deborah, Obisesan, Thomas O., Oke, Luc M., Adams, R.G., Neita, Marguerite, Lewis-Jack, Ometha, Blakely, Raymond, Vaccaro, Paul, Franks, B. Don, Dotson, Charles O.
Format: Article
Language:English
Subjects:
Adolescent
Adult
African Americans
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Black or African American
Black People
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Cardiovascular System
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Cohort Studies
Exercise
Family Health
Female
General aspects
Heart Rate
Humans
Hypertension
Hypertension - genetics
Hypertension - pathology
Medical sciences
Oxygen - metabolism
Parental history
Parents
United States
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Summary:Genetic and environmental hypotheses may explain why normotensive persons at high risk of developing hypertension often exhibit greater cardiovascular reactivity to stressors than those at low risk. Pearson’s correlation was used to evaluate reproducibility and independent t test to compare the cardiovascular responses to 30W of exercise of normotensive young adult African-American women with positive and negative parental histories (PH) of hypertension (PH+, n=23; PH−, n=20). Correlations were significant for duplicate measurements. The effects of PH on blood pressure measured at rest and during exercise were not statistically significant (P>0.1). A nearly significant trend for greater resting V˙O2 (P=0.08) was detected in the PH− than in the PH+ group (3.67±0.18 versus 3.26±0.14mL/kg/min). A hyper-reactive blood pressure response to exercise, characteristic of the evolution of hypertension, may not be present among the normotensive female offspring of hypertensive African Americans. The significance of an 11% intergroup difference in the mean resting V˙O2 observed in this study is unclear.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-200408000-00002