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Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood

Abstract Choline is a vital nutrient needed during early development for both humans and rodents. Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring...

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Published in:Brain research 2011-09, Vol.1413, p.84-97
Main Authors: Wong-Goodrich, Sarah J.E, Tognoni, Christina M, Mellott, Tiffany J, Glenn, Melissa J, Blusztajn, Jan K, Williams, Christina L
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container_title Brain research
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description Abstract Choline is a vital nutrient needed during early development for both humans and rodents. Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring that are accompanied by cognitive deficits only when task demands are high. Because prenatal choline supplementation confers neuroprotection of the adult hippocampus against a variety of neural insults and aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural injury. To examine this, adult offspring of rat dams either fed a control diet (CON) or one deficient in choline (DEF) during embryonic days 12–17 were given multiple injections (i.p.) of saline (control) or kainic acid to induce seizures and were euthanized 16 days later. Perhaps somewhat surprisingly, DEF rats were not more susceptible to seizure induction and showed similar levels of seizure-induced hippocampal histopathology, GAD expression loss, upregulated hippocampal GFAP and growth factor expression, and increased dentate cell and neuronal proliferation as that seen in CON rats. Although prenatal choline deficiency compromises adult hippocampal plasticity in the intact brain, it does not appear to exacerbate the neuropathological response to seizures in the adult hippocampus at least shortly after excitotoxic injury.
doi_str_mv 10.1016/j.brainres.2011.07.042
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Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring that are accompanied by cognitive deficits only when task demands are high. Because prenatal choline supplementation confers neuroprotection of the adult hippocampus against a variety of neural insults and aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural injury. To examine this, adult offspring of rat dams either fed a control diet (CON) or one deficient in choline (DEF) during embryonic days 12–17 were given multiple injections (i.p.) of saline (control) or kainic acid to induce seizures and were euthanized 16 days later. Perhaps somewhat surprisingly, DEF rats were not more susceptible to seizure induction and showed similar levels of seizure-induced hippocampal histopathology, GAD expression loss, upregulated hippocampal GFAP and growth factor expression, and increased dentate cell and neuronal proliferation as that seen in CON rats. Although prenatal choline deficiency compromises adult hippocampal plasticity in the intact brain, it does not appear to exacerbate the neuropathological response to seizures in the adult hippocampus at least shortly after excitotoxic injury.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2011.07.042</identifier><identifier>PMID: 21840511</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>adulthood ; adults ; Age Factors ; Animals ; Biological and medical sciences ; Choline ; Choline - administration &amp; dosage ; Choline Deficiency - chemically induced ; Choline Deficiency - metabolism ; cognition ; congenital abnormalities ; diet ; Disease Susceptibility ; early development ; Female ; Glial fibrillary acidic protein ; Glutamic acid decarboxylase ; Growth factor ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampus ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - metabolism ; histopathology ; humans ; Kainic Acid - toxicity ; Male ; Medical sciences ; memory ; Nervous system (semeiology, syndromes) ; Neurology ; neurons ; Neuroprotective Agents - administration &amp; dosage ; neuroprotective effect ; Pregnancy ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - metabolism ; progeny ; Rats ; Rats, Sprague-Dawley ; Seizure ; seizures ; Seizures - chemically induced ; Seizures - metabolism</subject><ispartof>Brain research, 2011-09, Vol.1413, p.84-97</ispartof><rights>Elsevier B.V.</rights><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><rights>2011 Elsevier B.V. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-5758d4d2a35cdc2be73b42f6eb627882520cf7a7211ff9585de669cfcf88587b3</citedby><cites>FETCH-LOGICAL-c611t-5758d4d2a35cdc2be73b42f6eb627882520cf7a7211ff9585de669cfcf88587b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=24544408$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21840511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong-Goodrich, Sarah J.E</creatorcontrib><creatorcontrib>Tognoni, Christina M</creatorcontrib><creatorcontrib>Mellott, Tiffany J</creatorcontrib><creatorcontrib>Glenn, Melissa J</creatorcontrib><creatorcontrib>Blusztajn, Jan K</creatorcontrib><creatorcontrib>Williams, Christina L</creatorcontrib><title>Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract Choline is a vital nutrient needed during early development for both humans and rodents. Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring that are accompanied by cognitive deficits only when task demands are high. Because prenatal choline supplementation confers neuroprotection of the adult hippocampus against a variety of neural insults and aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural injury. To examine this, adult offspring of rat dams either fed a control diet (CON) or one deficient in choline (DEF) during embryonic days 12–17 were given multiple injections (i.p.) of saline (control) or kainic acid to induce seizures and were euthanized 16 days later. Perhaps somewhat surprisingly, DEF rats were not more susceptible to seizure induction and showed similar levels of seizure-induced hippocampal histopathology, GAD expression loss, upregulated hippocampal GFAP and growth factor expression, and increased dentate cell and neuronal proliferation as that seen in CON rats. Although prenatal choline deficiency compromises adult hippocampal plasticity in the intact brain, it does not appear to exacerbate the neuropathological response to seizures in the adult hippocampus at least shortly after excitotoxic injury.</description><subject>adulthood</subject><subject>adults</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Choline</subject><subject>Choline - administration &amp; dosage</subject><subject>Choline Deficiency - chemically induced</subject><subject>Choline Deficiency - metabolism</subject><subject>cognition</subject><subject>congenital abnormalities</subject><subject>diet</subject><subject>Disease Susceptibility</subject><subject>early development</subject><subject>Female</subject><subject>Glial fibrillary acidic protein</subject><subject>Glutamic acid decarboxylase</subject><subject>Growth factor</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hippocampus</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>histopathology</subject><subject>humans</subject><subject>Kainic Acid - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>memory</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>neurons</subject><subject>Neuroprotective Agents - administration &amp; dosage</subject><subject>neuroprotective effect</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prenatal Exposure Delayed Effects - metabolism</subject><subject>progeny</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Seizure</subject><subject>seizures</subject><subject>Seizures - chemically induced</subject><subject>Seizures - metabolism</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkktvEzEURkcIREvhLxRvEKsJtmf8mE0FqnhJlUAqXVse-7px6tjBnokUfj0OSctjw8qyfO53r3xu05wTvCCY8DerxZi1jxnKgmJCFlgscE8fNadECtpy2uPHzSnGmLdyGLqT5lkpq3rtugE_bU4okT1mhJw2268Zop50QGaZgo-ALDhvPESzQzZBQTFNCOJSRwNo6TebZPR6U_ntHCJkPfrgpx3SboKM7upI3iBtvG19tLMBiwr4H3OdE_mItJ3DtEzJPm-eOB0KvDieZ83Nh_ffLj-1V18-fr58d9UaTsjUMsGk7S3VHTPW0BFEN_bUcRg5FVJSRrFxQgtKiHMDk8wC54NxxknJpBi7s-bikLuZxzVYA3HKOqhN9muddyppr_5-iX6pbtNWdaQG8aEGvD4G5PR9hjKptS8GQtAR0lzUgAUZyMB4JfmBNDmVksE9dCFY7Z2plbp3pvbOFBaqOquF53_O-FB2L6kCr46ALkYHl6sLX35zPev7HsvKvTxwTielb3Nlbq5rJ1bFD50kohJvDwTUP996yKr8Ug3WZzCTssn_f9qLfyJM2EvX4Q52UFZpzrEaVUQVqrC63u_gfgVJDe16ybqf3r7aZA</recordid><startdate>20110921</startdate><enddate>20110921</enddate><creator>Wong-Goodrich, Sarah J.E</creator><creator>Tognoni, Christina M</creator><creator>Mellott, Tiffany J</creator><creator>Glenn, Melissa J</creator><creator>Blusztajn, Jan K</creator><creator>Williams, Christina L</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20110921</creationdate><title>Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood</title><author>Wong-Goodrich, Sarah J.E ; Tognoni, Christina M ; Mellott, Tiffany J ; Glenn, Melissa J ; Blusztajn, Jan K ; Williams, Christina L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-5758d4d2a35cdc2be73b42f6eb627882520cf7a7211ff9585de669cfcf88587b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>adulthood</topic><topic>adults</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Choline</topic><topic>Choline - administration &amp; dosage</topic><topic>Choline Deficiency - chemically induced</topic><topic>Choline Deficiency - metabolism</topic><topic>cognition</topic><topic>congenital abnormalities</topic><topic>diet</topic><topic>Disease Susceptibility</topic><topic>early development</topic><topic>Female</topic><topic>Glial fibrillary acidic protein</topic><topic>Glutamic acid decarboxylase</topic><topic>Growth factor</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. 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source ScienceDirect Journals
subjects adulthood
adults
Age Factors
Animals
Biological and medical sciences
Choline
Choline - administration & dosage
Choline Deficiency - chemically induced
Choline Deficiency - metabolism
cognition
congenital abnormalities
diet
Disease Susceptibility
early development
Female
Glial fibrillary acidic protein
Glutamic acid decarboxylase
Growth factor
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampus
Hippocampus - cytology
Hippocampus - drug effects
Hippocampus - metabolism
histopathology
humans
Kainic Acid - toxicity
Male
Medical sciences
memory
Nervous system (semeiology, syndromes)
Neurology
neurons
Neuroprotective Agents - administration & dosage
neuroprotective effect
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Prenatal Exposure Delayed Effects - metabolism
progeny
Rats
Rats, Sprague-Dawley
Seizure
seizures
Seizures - chemically induced
Seizures - metabolism
title Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood
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