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Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood
Abstract Choline is a vital nutrient needed during early development for both humans and rodents. Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring...
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Published in: | Brain research 2011-09, Vol.1413, p.84-97 |
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description | Abstract Choline is a vital nutrient needed during early development for both humans and rodents. Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring that are accompanied by cognitive deficits only when task demands are high. Because prenatal choline supplementation confers neuroprotection of the adult hippocampus against a variety of neural insults and aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural injury. To examine this, adult offspring of rat dams either fed a control diet (CON) or one deficient in choline (DEF) during embryonic days 12–17 were given multiple injections (i.p.) of saline (control) or kainic acid to induce seizures and were euthanized 16 days later. Perhaps somewhat surprisingly, DEF rats were not more susceptible to seizure induction and showed similar levels of seizure-induced hippocampal histopathology, GAD expression loss, upregulated hippocampal GFAP and growth factor expression, and increased dentate cell and neuronal proliferation as that seen in CON rats. Although prenatal choline deficiency compromises adult hippocampal plasticity in the intact brain, it does not appear to exacerbate the neuropathological response to seizures in the adult hippocampus at least shortly after excitotoxic injury. |
doi_str_mv | 10.1016/j.brainres.2011.07.042 |
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Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring that are accompanied by cognitive deficits only when task demands are high. Because prenatal choline supplementation confers neuroprotection of the adult hippocampus against a variety of neural insults and aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural injury. To examine this, adult offspring of rat dams either fed a control diet (CON) or one deficient in choline (DEF) during embryonic days 12–17 were given multiple injections (i.p.) of saline (control) or kainic acid to induce seizures and were euthanized 16 days later. Perhaps somewhat surprisingly, DEF rats were not more susceptible to seizure induction and showed similar levels of seizure-induced hippocampal histopathology, GAD expression loss, upregulated hippocampal GFAP and growth factor expression, and increased dentate cell and neuronal proliferation as that seen in CON rats. Although prenatal choline deficiency compromises adult hippocampal plasticity in the intact brain, it does not appear to exacerbate the neuropathological response to seizures in the adult hippocampus at least shortly after excitotoxic injury.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2011.07.042</identifier><identifier>PMID: 21840511</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>adulthood ; adults ; Age Factors ; Animals ; Biological and medical sciences ; Choline ; Choline - administration & dosage ; Choline Deficiency - chemically induced ; Choline Deficiency - metabolism ; cognition ; congenital abnormalities ; diet ; Disease Susceptibility ; early development ; Female ; Glial fibrillary acidic protein ; Glutamic acid decarboxylase ; Growth factor ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampus ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - metabolism ; histopathology ; humans ; Kainic Acid - toxicity ; Male ; Medical sciences ; memory ; Nervous system (semeiology, syndromes) ; Neurology ; neurons ; Neuroprotective Agents - administration & dosage ; neuroprotective effect ; Pregnancy ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - metabolism ; progeny ; Rats ; Rats, Sprague-Dawley ; Seizure ; seizures ; Seizures - chemically induced ; Seizures - metabolism</subject><ispartof>Brain research, 2011-09, Vol.1413, p.84-97</ispartof><rights>Elsevier B.V.</rights><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><rights>2011 Elsevier B.V. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-5758d4d2a35cdc2be73b42f6eb627882520cf7a7211ff9585de669cfcf88587b3</citedby><cites>FETCH-LOGICAL-c611t-5758d4d2a35cdc2be73b42f6eb627882520cf7a7211ff9585de669cfcf88587b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24544408$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21840511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong-Goodrich, Sarah J.E</creatorcontrib><creatorcontrib>Tognoni, Christina M</creatorcontrib><creatorcontrib>Mellott, Tiffany J</creatorcontrib><creatorcontrib>Glenn, Melissa J</creatorcontrib><creatorcontrib>Blusztajn, Jan K</creatorcontrib><creatorcontrib>Williams, Christina L</creatorcontrib><title>Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract Choline is a vital nutrient needed during early development for both humans and rodents. Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring that are accompanied by cognitive deficits only when task demands are high. Because prenatal choline supplementation confers neuroprotection of the adult hippocampus against a variety of neural insults and aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural injury. To examine this, adult offspring of rat dams either fed a control diet (CON) or one deficient in choline (DEF) during embryonic days 12–17 were given multiple injections (i.p.) of saline (control) or kainic acid to induce seizures and were euthanized 16 days later. Perhaps somewhat surprisingly, DEF rats were not more susceptible to seizure induction and showed similar levels of seizure-induced hippocampal histopathology, GAD expression loss, upregulated hippocampal GFAP and growth factor expression, and increased dentate cell and neuronal proliferation as that seen in CON rats. Although prenatal choline deficiency compromises adult hippocampal plasticity in the intact brain, it does not appear to exacerbate the neuropathological response to seizures in the adult hippocampus at least shortly after excitotoxic injury.</description><subject>adulthood</subject><subject>adults</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Choline</subject><subject>Choline - administration & dosage</subject><subject>Choline Deficiency - chemically induced</subject><subject>Choline Deficiency - metabolism</subject><subject>cognition</subject><subject>congenital abnormalities</subject><subject>diet</subject><subject>Disease Susceptibility</subject><subject>early development</subject><subject>Female</subject><subject>Glial fibrillary acidic protein</subject><subject>Glutamic acid decarboxylase</subject><subject>Growth factor</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hippocampus</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>histopathology</subject><subject>humans</subject><subject>Kainic Acid - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>memory</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>neurons</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>neuroprotective effect</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prenatal Exposure Delayed Effects - metabolism</subject><subject>progeny</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Seizure</subject><subject>seizures</subject><subject>Seizures - chemically induced</subject><subject>Seizures - metabolism</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkktvEzEURkcIREvhLxRvEKsJtmf8mE0FqnhJlUAqXVse-7px6tjBnokUfj0OSctjw8qyfO53r3xu05wTvCCY8DerxZi1jxnKgmJCFlgscE8fNadECtpy2uPHzSnGmLdyGLqT5lkpq3rtugE_bU4okT1mhJw2268Zop50QGaZgo-ALDhvPESzQzZBQTFNCOJSRwNo6TebZPR6U_ntHCJkPfrgpx3SboKM7upI3iBtvG19tLMBiwr4H3OdE_mItJ3DtEzJPm-eOB0KvDieZ83Nh_ffLj-1V18-fr58d9UaTsjUMsGk7S3VHTPW0BFEN_bUcRg5FVJSRrFxQgtKiHMDk8wC54NxxknJpBi7s-bikLuZxzVYA3HKOqhN9muddyppr_5-iX6pbtNWdaQG8aEGvD4G5PR9hjKptS8GQtAR0lzUgAUZyMB4JfmBNDmVksE9dCFY7Z2plbp3pvbOFBaqOquF53_O-FB2L6kCr46ALkYHl6sLX35zPev7HsvKvTxwTielb3Nlbq5rJ1bFD50kohJvDwTUP996yKr8Ug3WZzCTssn_f9qLfyJM2EvX4Q52UFZpzrEaVUQVqrC63u_gfgVJDe16ybqf3r7aZA</recordid><startdate>20110921</startdate><enddate>20110921</enddate><creator>Wong-Goodrich, Sarah J.E</creator><creator>Tognoni, Christina M</creator><creator>Mellott, Tiffany J</creator><creator>Glenn, Melissa J</creator><creator>Blusztajn, Jan K</creator><creator>Williams, Christina L</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20110921</creationdate><title>Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood</title><author>Wong-Goodrich, Sarah J.E ; Tognoni, Christina M ; Mellott, Tiffany J ; Glenn, Melissa J ; Blusztajn, Jan K ; Williams, Christina L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-5758d4d2a35cdc2be73b42f6eb627882520cf7a7211ff9585de669cfcf88587b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>adulthood</topic><topic>adults</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Choline</topic><topic>Choline - administration & dosage</topic><topic>Choline Deficiency - chemically induced</topic><topic>Choline Deficiency - metabolism</topic><topic>cognition</topic><topic>congenital abnormalities</topic><topic>diet</topic><topic>Disease Susceptibility</topic><topic>early development</topic><topic>Female</topic><topic>Glial fibrillary acidic protein</topic><topic>Glutamic acid decarboxylase</topic><topic>Growth factor</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hippocampus</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>histopathology</topic><topic>humans</topic><topic>Kainic Acid - toxicity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>memory</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>neurons</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>neuroprotective effect</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - chemically induced</topic><topic>Prenatal Exposure Delayed Effects - metabolism</topic><topic>progeny</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Seizure</topic><topic>seizures</topic><topic>Seizures - chemically induced</topic><topic>Seizures - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong-Goodrich, Sarah J.E</creatorcontrib><creatorcontrib>Tognoni, Christina M</creatorcontrib><creatorcontrib>Mellott, Tiffany J</creatorcontrib><creatorcontrib>Glenn, Melissa J</creatorcontrib><creatorcontrib>Blusztajn, Jan K</creatorcontrib><creatorcontrib>Williams, Christina L</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong-Goodrich, Sarah J.E</au><au>Tognoni, Christina M</au><au>Mellott, Tiffany J</au><au>Glenn, Melissa J</au><au>Blusztajn, Jan K</au><au>Williams, Christina L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2011-09-21</date><risdate>2011</risdate><volume>1413</volume><spage>84</spage><epage>97</epage><pages>84-97</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Abstract Choline is a vital nutrient needed during early development for both humans and rodents. Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring that are accompanied by cognitive deficits only when task demands are high. Because prenatal choline supplementation confers neuroprotection of the adult hippocampus against a variety of neural insults and aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural injury. To examine this, adult offspring of rat dams either fed a control diet (CON) or one deficient in choline (DEF) during embryonic days 12–17 were given multiple injections (i.p.) of saline (control) or kainic acid to induce seizures and were euthanized 16 days later. Perhaps somewhat surprisingly, DEF rats were not more susceptible to seizure induction and showed similar levels of seizure-induced hippocampal histopathology, GAD expression loss, upregulated hippocampal GFAP and growth factor expression, and increased dentate cell and neuronal proliferation as that seen in CON rats. Although prenatal choline deficiency compromises adult hippocampal plasticity in the intact brain, it does not appear to exacerbate the neuropathological response to seizures in the adult hippocampus at least shortly after excitotoxic injury.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21840511</pmid><doi>10.1016/j.brainres.2011.07.042</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | adulthood adults Age Factors Animals Biological and medical sciences Choline Choline - administration & dosage Choline Deficiency - chemically induced Choline Deficiency - metabolism cognition congenital abnormalities diet Disease Susceptibility early development Female Glial fibrillary acidic protein Glutamic acid decarboxylase Growth factor Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism histopathology humans Kainic Acid - toxicity Male Medical sciences memory Nervous system (semeiology, syndromes) Neurology neurons Neuroprotective Agents - administration & dosage neuroprotective effect Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - metabolism progeny Rats Rats, Sprague-Dawley Seizure seizures Seizures - chemically induced Seizures - metabolism |
title | Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood |
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