Loading…

Proteasomal regulation of nuclear receptor corepressor-mediated repression

Repression of gene transcription is a fundamental property of nuclear hormone receptors. We report here that cell-specific repression by nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein. N-CoR protein levels are regulated by mSiah2, a mammalian homolog of Dros...

Full description

Saved in:

Bibliographic Details
Published in:	Genes & development 1998-06, Vol.12 (12), p.1775-1780
Main Authors:	Zhang, J, Guenther, M G, Carthew, R W, Lazar, M A
Format:	Article
Language:	English
Subjects:	Animals Cell Line, Transformed Cysteine Endopeptidases - metabolism Drosophila - chemistry Eukaryotic Cells - cytology Eukaryotic Cells - metabolism Gene Expression Regulation Humans Hydrolysis Multienzyme Complexes - metabolism Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Proteins - physiology Nuclear Receptor Co-Repressor 1 Proteasome Endopeptidase Complex Recombinant Proteins - genetics Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Repressor Proteins - physiology Research Communication Trans-Activators - genetics Trans-Activators - physiology Transcription, Genetic - genetics Transcriptional Activation Ubiquitin-Protein Ligases
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c481t-b5cbcfc94473a4badefb70b096457912c8f0ba34c8bd4e89f9df73d2748c82493
cites	cdi_FETCH-LOGICAL-c481t-b5cbcfc94473a4badefb70b096457912c8f0ba34c8bd4e89f9df73d2748c82493
container_end_page	1780
container_issue	12
container_start_page	1775
container_title	Genes & development
container_volume	12
creator	Zhang, J Guenther, M G Carthew, R W Lazar, M A
description	Repression of gene transcription is a fundamental property of nuclear hormone receptors. We report here that cell-specific repression by nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein. N-CoR protein levels are regulated by mSiah2, a mammalian homolog of Drosophila Seven in absentia that targets N-CoR for proteasomal degradation. mSiah2 expression is cell-type specific and differentially regulates the repressive activities of nuclear receptors. These findings establish targeted proteolysis of transcriptional coregulators as a mechanism for cell-specific regulation of gene transcription.
doi_str_mv	10.1101/gad.12.12.1775
format	article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_316907</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16476682</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-b5cbcfc94473a4badefb70b096457912c8f0ba34c8bd4e89f9df73d2748c82493</originalsourceid><addsrcrecordid>eNqFUU1LxDAQDaKs6-rVm9CTt65Jk-bj4EEWP1nQg55DkiZrpdvUpBX892Z3y6InYWDgzXvDm3kAnCM4Rwiiq5Wq5qjYFmPlAZiikoi8JIwdginkAuYCU3EMTmL8gBBSSOkETATFjDIxBU8vwfdWRb9WTRbsamhUX_s28y5rB9NYFRJqbNf7kBkfbBdsjD7ka1vVqrdVNkJJcwqOnGqiPRv7DLzd3b4uHvLl8_3j4maZG8JRn-vSaOOMIIRhRbSqrNMMaigoKZlAheEOaoWJ4boilgsnKsdwVTDCDS-IwDNwvdvbDTrZMLbtg2pkF-q1Ct_Sq1r-nbT1u1z5L4kRFZAl_eWoD_5zsLGX6zoa2zSqtX6IkglRpv8V_xIRJYxSviHOd0QTfIzBur0ZBOUmJZlSkqjYVkopCS5-n7Cnj7HgHyAakS4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16476682</pqid></control><display><type>article</type><title>Proteasomal regulation of nuclear receptor corepressor-mediated repression</title><source>Freely Accessible Journals</source><source>Open Access: PubMed Central</source><creator>Zhang, J ; Guenther, M G ; Carthew, R W ; Lazar, M A</creator><creatorcontrib>Zhang, J ; Guenther, M G ; Carthew, R W ; Lazar, M A</creatorcontrib><description>Repression of gene transcription is a fundamental property of nuclear hormone receptors. We report here that cell-specific repression by nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein. N-CoR protein levels are regulated by mSiah2, a mammalian homolog of Drosophila Seven in absentia that targets N-CoR for proteasomal degradation. mSiah2 expression is cell-type specific and differentially regulates the repressive activities of nuclear receptors. These findings establish targeted proteolysis of transcriptional coregulators as a mechanism for cell-specific regulation of gene transcription.</description><identifier>ISSN: 0890-9369</identifier><identifier>EISSN: 1549-5477</identifier><identifier>DOI: 10.1101/gad.12.12.1775</identifier><identifier>PMID: 9637679</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Animals ; Cell Line, Transformed ; Cysteine Endopeptidases - metabolism ; Drosophila - chemistry ; Eukaryotic Cells - cytology ; Eukaryotic Cells - metabolism ; Gene Expression Regulation ; Humans ; Hydrolysis ; Multienzyme Complexes - metabolism ; Nuclear Proteins - chemistry ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Nuclear Proteins - physiology ; Nuclear Receptor Co-Repressor 1 ; Proteasome Endopeptidase Complex ; Recombinant Proteins - genetics ; Repressor Proteins - chemistry ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Repressor Proteins - physiology ; Research Communication ; Trans-Activators - genetics ; Trans-Activators - physiology ; Transcription, Genetic - genetics ; Transcriptional Activation ; Ubiquitin-Protein Ligases</subject><ispartof>Genes & development, 1998-06, Vol.12 (12), p.1775-1780</ispartof><rights>Copyright © 1998, Cold Spring Harbor Laboratory Press 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-b5cbcfc94473a4badefb70b096457912c8f0ba34c8bd4e89f9df73d2748c82493</citedby><cites>FETCH-LOGICAL-c481t-b5cbcfc94473a4badefb70b096457912c8f0ba34c8bd4e89f9df73d2748c82493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC316907/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC316907/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9637679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Guenther, M G</creatorcontrib><creatorcontrib>Carthew, R W</creatorcontrib><creatorcontrib>Lazar, M A</creatorcontrib><title>Proteasomal regulation of nuclear receptor corepressor-mediated repression</title><title>Genes & development</title><addtitle>Genes Dev</addtitle><description>Repression of gene transcription is a fundamental property of nuclear hormone receptors. We report here that cell-specific repression by nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein. N-CoR protein levels are regulated by mSiah2, a mammalian homolog of Drosophila Seven in absentia that targets N-CoR for proteasomal degradation. mSiah2 expression is cell-type specific and differentially regulates the repressive activities of nuclear receptors. These findings establish targeted proteolysis of transcriptional coregulators as a mechanism for cell-specific regulation of gene transcription.</description><subject>Animals</subject><subject>Cell Line, Transformed</subject><subject>Cysteine Endopeptidases - metabolism</subject><subject>Drosophila - chemistry</subject><subject>Eukaryotic Cells - cytology</subject><subject>Eukaryotic Cells - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Hydrolysis</subject><subject>Multienzyme Complexes - metabolism</subject><subject>Nuclear Proteins - chemistry</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Nuclear Proteins - physiology</subject><subject>Nuclear Receptor Co-Repressor 1</subject><subject>Proteasome Endopeptidase Complex</subject><subject>Recombinant Proteins - genetics</subject><subject>Repressor Proteins - chemistry</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>Repressor Proteins - physiology</subject><subject>Research Communication</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - physiology</subject><subject>Transcription, Genetic - genetics</subject><subject>Transcriptional Activation</subject><subject>Ubiquitin-Protein Ligases</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFUU1LxDAQDaKs6-rVm9CTt65Jk-bj4EEWP1nQg55DkiZrpdvUpBX892Z3y6InYWDgzXvDm3kAnCM4Rwiiq5Wq5qjYFmPlAZiikoi8JIwdginkAuYCU3EMTmL8gBBSSOkETATFjDIxBU8vwfdWRb9WTRbsamhUX_s28y5rB9NYFRJqbNf7kBkfbBdsjD7ka1vVqrdVNkJJcwqOnGqiPRv7DLzd3b4uHvLl8_3j4maZG8JRn-vSaOOMIIRhRbSqrNMMaigoKZlAheEOaoWJ4boilgsnKsdwVTDCDS-IwDNwvdvbDTrZMLbtg2pkF-q1Ct_Sq1r-nbT1u1z5L4kRFZAl_eWoD_5zsLGX6zoa2zSqtX6IkglRpv8V_xIRJYxSviHOd0QTfIzBur0ZBOUmJZlSkqjYVkopCS5-n7Cnj7HgHyAakS4</recordid><startdate>19980615</startdate><enddate>19980615</enddate><creator>Zhang, J</creator><creator>Guenther, M G</creator><creator>Carthew, R W</creator><creator>Lazar, M A</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19980615</creationdate><title>Proteasomal regulation of nuclear receptor corepressor-mediated repression</title><author>Zhang, J ; Guenther, M G ; Carthew, R W ; Lazar, M A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-b5cbcfc94473a4badefb70b096457912c8f0ba34c8bd4e89f9df73d2748c82493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Cell Line, Transformed</topic><topic>Cysteine Endopeptidases - metabolism</topic><topic>Drosophila - chemistry</topic><topic>Eukaryotic Cells - cytology</topic><topic>Eukaryotic Cells - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Hydrolysis</topic><topic>Multienzyme Complexes - metabolism</topic><topic>Nuclear Proteins - chemistry</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Nuclear Proteins - physiology</topic><topic>Nuclear Receptor Co-Repressor 1</topic><topic>Proteasome Endopeptidase Complex</topic><topic>Recombinant Proteins - genetics</topic><topic>Repressor Proteins - chemistry</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>Repressor Proteins - physiology</topic><topic>Research Communication</topic><topic>Trans-Activators - genetics</topic><topic>Trans-Activators - physiology</topic><topic>Transcription, Genetic - genetics</topic><topic>Transcriptional Activation</topic><topic>Ubiquitin-Protein Ligases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Guenther, M G</creatorcontrib><creatorcontrib>Carthew, R W</creatorcontrib><creatorcontrib>Lazar, M A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, J</au><au>Guenther, M G</au><au>Carthew, R W</au><au>Lazar, M A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proteasomal regulation of nuclear receptor corepressor-mediated repression</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>1998-06-15</date><risdate>1998</risdate><volume>12</volume><issue>12</issue><spage>1775</spage><epage>1780</epage><pages>1775-1780</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><abstract>Repression of gene transcription is a fundamental property of nuclear hormone receptors. We report here that cell-specific repression by nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein. N-CoR protein levels are regulated by mSiah2, a mammalian homolog of Drosophila Seven in absentia that targets N-CoR for proteasomal degradation. mSiah2 expression is cell-type specific and differentially regulates the repressive activities of nuclear receptors. These findings establish targeted proteolysis of transcriptional coregulators as a mechanism for cell-specific regulation of gene transcription.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>9637679</pmid><doi>10.1101/gad.12.12.1775</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0890-9369
ispartof	Genes & development, 1998-06, Vol.12 (12), p.1775-1780
issn	0890-9369 1549-5477
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_316907
source	Freely Accessible Journals; Open Access: PubMed Central
subjects	Animals Cell Line, Transformed Cysteine Endopeptidases - metabolism Drosophila - chemistry Eukaryotic Cells - cytology Eukaryotic Cells - metabolism Gene Expression Regulation Humans Hydrolysis Multienzyme Complexes - metabolism Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Proteins - physiology Nuclear Receptor Co-Repressor 1 Proteasome Endopeptidase Complex Recombinant Proteins - genetics Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Repressor Proteins - physiology Research Communication Trans-Activators - genetics Trans-Activators - physiology Transcription, Genetic - genetics Transcriptional Activation Ubiquitin-Protein Ligases
title	Proteasomal regulation of nuclear receptor corepressor-mediated repression
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T05%3A52%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Proteasomal%20regulation%20of%20nuclear%20receptor%20corepressor-mediated%20repression&rft.jtitle=Genes%20&%20development&rft.au=Zhang,%20J&rft.date=1998-06-15&rft.volume=12&rft.issue=12&rft.spage=1775&rft.epage=1780&rft.pages=1775-1780&rft.issn=0890-9369&rft.eissn=1549-5477&rft_id=info:doi/10.1101/gad.12.12.1775&rft_dat=%3Cproquest_pubme%3E16476682%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c481t-b5cbcfc94473a4badefb70b096457912c8f0ba34c8bd4e89f9df73d2748c82493%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=16476682&rft_id=info:pmid/9637679&rfr_iscdi=true