Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome

• Published in: Journal of assisted reproduction and genetics 2011-09, Vol.28 (9), p.869-875
• Main Authors: Vural, Pervin, Kanmaz-Özer, Müge, Doğru-Abbasoğlu, Semra, Gedikbaşı, Ali, Çil, Esra, Karadağ, Berrin, Uysal, Müjdat
• Format: Article
• Language: English
• Subjects: Adult; Amenorrhea; Antigens; Cardiovascular disease; Diabetes; Female; Genetic Predisposition to Disease; Genotype; Glucose; Gonadal Physiology and Disease; Gynecology; Haplotypes; Human Genetics; Humans; Infertility; Inflammation; Insulin resistance; Insulin Resistance - genetics; Intercellular Adhesion Molecule-1 - genetics; Leukocytes; Medicine; Medicine & Public Health; Menstruation; Ovaries; Polycystic ovary syndrome; Polycystic Ovary Syndrome - genetics; Polymorphism, Single Nucleotide; Reproductive Medicine; Risk Factors
• ISSN: 1058-0468; 1573-7330
• DOI: 10.1007/s10815-011-9607-8

Purpose This study examined the possible association of G241R and K469E single nucleotide polymorphisms (SNPs) of ICAM-1 gene with the occurrence and clinical/biochemical characteristics of polycystic ovary syndrome (PCOS). Methods G241R and K469E SNPs in DNA from peripheral blood leukocytes of 169 PCOS and 259 healthy control women were investigated by real-time PCR combined with melting curve analysis using fluorescence-labeled hybridization probes. Results We did not find significant differences in the distributions of G241R and K469E polymorphisms, nor in the haplotype frequencies between PCOS and control women. None of the studied polymorphisms were found to affect insulin resistance indices significantly. Conclusions These preliminary results suggest that the 241 and 469 SNPs of ICAM-1 gene may not be risk factors for PCOS. Further studies with a larger cohort, analyzing other ICAM-1 polymorphisms are necessary to support our observations before any statement can be made about the relationship between PCOS and ICAM-1 polymorphisms.