Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

The development and use of sensitizing agents to improve the effectiveness of radiotherapy have long been sought to improve our ability to treat cancer. In this letter, we have studied the relative biological effectiveness of proton beam radiotherapy on prostate tumor cells with and without internal...

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Bibliographic Details
Published in:Applied physics letters 2011-05, Vol.98 (19), p.193702-193702-3
Main Authors: Polf, Jerimy C., Bronk, Lawrence F., Driessen, Wouter H. P., Arap, Wadih, Pasqualini, Renata, Gillin, Michael
Format: Article
Language:English
Subjects:
ANIMAL CELLS
BARYONS
BEAMS
BIOPHYSICS
Biophysics and Bio-Inspired Systems
BODY
DISEASES
ELEMENTARY PARTICLES
ELEMENTS
FERMIONS
GLANDS
GOLD
HADRONS
MALE GENITALS
MEDICINE
METALS
NANOSTRUCTURES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEON BEAMS
NUCLEONS
ORGANS
PARTICLE BEAMS
PARTICLES
PHYSICS
PROSTATE
PROTON BEAMS
PROTONS
RADIOLOGY
RADIOLOGY AND NUCLEAR MEDICINE
RADIOTHERAPY
RBE
THERAPY
TRANSITION ELEMENTS
TUMOR CELLS
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Summary:The development and use of sensitizing agents to improve the effectiveness of radiotherapy have long been sought to improve our ability to treat cancer. In this letter, we have studied the relative biological effectiveness of proton beam radiotherapy on prostate tumor cells with and without internalized gold nanoparticles. The effectiveness of proton radiotherapy for the killing of prostate tumor cells was increased by approximately 15%-20% for those cells containing internalized gold nanoparticles.
ISSN:0003-6951
1077-3118
0003-6951
DOI:10.1063/1.3589914