Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa

In a previous work based on popular belief, Campomanesia xanthocarpa Berg., popularly known as “guavirova”, showed to have a potential effect in the control of a number of conditions associated with cardiovascular diseases. The aim of the present work was to investigate the effects of C. xanthocarpa...

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Published in:Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-8
Main Authors: Medeiros Frescura Duarte, Marta Maria, Soares dos Santos, Adair Roberto, Nazário Viecili, Paulo Ricardo, Ferreira, Juliano, Schetinger, Maria Rosa Chitolina, Olschowsky Borges, Diego, Leal, Cláudio Alberto Martins, Banderó Walker, Cristiani Isabel, Trevisan, Gabriela, Fortes Rossato, Mateus, Arnoldi da Silva, Mariane, Klafke, Jonatas Zeni, Noal Moresco, Rafael
Format: Article
Language:English
Subjects:
Acetylsalicylic acid
Adenosine diphosphate
Atherosclerosis
Blood coagulation
Blood platelets
Cardiovascular diseases
Cytotoxicity
Disease prevention
Fibrin
Laboratory animals
Mice
Oral administration
Platelet aggregation
Prothrombin
R&D
Research & development
Thromboembolism
Thromboplastin
Thrombosis
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Summary:In a previous work based on popular belief, Campomanesia xanthocarpa Berg., popularly known as “guavirova”, showed to have a potential effect in the control of a number of conditions associated with cardiovascular diseases. The aim of the present work was to investigate the effects of C. xanthocarpa extract (CXE) on antiplatelet, antithrombotic and fibrinolytic activities in mice and in human blood. Mice were treated orally for 5 days with CXE or acetylsalicylic acid and at the end of the treatment period animals were challenged for bleeding, acute thromboembolism and ulcerogenic activity. In addition, we have assessed the prothrombin time and activated partial thromboplastin time (aPTT) after oral administration. In in vitro assays, antiplatelet effects of CXE was evaluated on platelet aggregation, and fibrinolytic activity of the extract was observed by mice or human artificial blood clot degradation. Platelet citotoxicity of the extract was also determined by the LDH assay. Results demonstrated that CXE has a significant protective effect on thrombosis. It also inhibits platelet aggregation without demonstrating cytotoxicity on platelets. CXE slightly prolonged aPTT and showed no ulcerogenic activity after oral administration. In addition, CXE showed a fibrinolytic activity. Thus, C. xanthocarpa showed antiplatelet, antithrombotic and fibrinolytic activities in mice.
ISSN:1741-427X
1741-4288
DOI:10.1155/2012/954748