Labeled acetate as a marker of astrocytic metabolism

Astrocytes have various important roles in brain physiology. To further elucidate the details of astrocytic functions under normal and pathological states, astrocyte-specific measurements are mandatory. For studying brain energy metabolism, the use of the astrocyte-specific energy substrate acetate...

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Bibliographic Details
Published in:Journal of Cerebral Blood Flow & Metabolism 2011-08, Vol.31 (8), p.1668-1674
Main Authors: Wyss, Matthias T, Magistretti, Pierre J, Buck, Alfred, Weber, Bruno
Format: Article
Language:English
Subjects:
Acetates
Acetic acid
Analgesics
Animals
Astrocytes
Astrocytes - metabolism
Biological and medical sciences
Brain
Carbon
Carbon Isotopes
Cerebral blood flow
Energy metabolism
Energy resources
Humans
Isotopes
Medical sciences
Mini Review
Molecular Probes - chemistry
Neurology
Neuropharmacology
Pharmacology. Drug treatments
Reviews
Vascular diseases and vascular malformations of the nervous system
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Summary:Astrocytes have various important roles in brain physiology. To further elucidate the details of astrocytic functions under normal and pathological states, astrocyte-specific measurements are mandatory. For studying brain energy metabolism, the use of the astrocyte-specific energy substrate acetate has proven to be of great value. Since the first applications of labeled acetate for brain studies about 50 years ago, numerous methodologies have been developed and employed in compartment-specific investigations of brain metabolism. Here, we provide an overview of these different methodological approaches and review studies employing acetate labeled with the most commonly used carbon isotopes.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.2011.84