Adiponectin gene and risk of colorectal cancer

• Published in: British journal of cancer 2011-08, Vol.105 (4), p.562-564
• Main Authors: Gornick, M C, Rennert, G, Moreno, V, Gruber, S B
• Format: Article
• Language: English
• Subjects: 631/208/457/649; 692/699/67/1504/1885; Adiponectin - genetics; Aged; Aged, 80 and over; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Colorectal cancer; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - genetics; Confidence intervals; Drug Resistance; Epidemiology; Ethnicity; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gene Frequency; Genes; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomes; Genotype; Health services; Humans; Hypotheses; Israel - epidemiology; Jewish people; Jews - genetics; Jews - statistics & numerical data; Male; Medical research; Medical sciences; Medicine; Middle Aged; Molecular Medicine; Obesity; Odds Ratio; Oncology; Polymorphism; Polymorphism, Single Nucleotide; Risk Assessment; Short Communication; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/bjc.2011.259

Background: Genes of the adiponectin pathway are interesting candidates for colorectal cancer risk based on the potential association between colorectal cancer and obesity. However, variants of the adiponectin gene ( ADIPOQ ) have been demonstrated to be inconsistently associated with risk of colorectal cancer. Methods: The current study attempted to evaluate these findings by examining several single nucleotide polymorphisms (SNPs) that were previously genotyped as part of a genome-wide association study in the ADIPOQ gene. Genotyping was also performed for a previously reported risk variant, rs266729, in 1062 individuals with a diagnosis of colorectal cancer and 1062 controls matched on age, gender and ethnicity (Jewish or not Jewish) as part of a population-based case–control study in Israel. Results: No evidence was found for an association between ADIPOQ and risk of colorectal cancer. The single nucleotide variant previously associated with decreased risk of colorectal cancer, rs266729, revealed an adjusted odds ratio of 1.04; 95% confidence interval, 0.88–1.23. Conclusion: The SNP, rs266729, was not strongly associated with colorectal cancer in patients of Ashkenazi Jewish descent or other ethnic groups in Israel.