Biology's response to dieting: the impetus for weight regain

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2011-09, Vol.301 (3), p.R581-R600
• Main Authors: MACLEAN, Paul S, BERGOUIGNAN, Audrey, CORNIER, Marc-Andre, JACKMAN, Matthew R
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological; Adipose Tissue - metabolism; Adipose Tissue - physiopathology; Adults; Animals; Biological and medical sciences; Biology; Caloric Restriction - adverse effects; Diet; Diet, Reducing - adverse effects; Fundamental and applied biological sciences. Psychology; Homeostasis; Humans; Medical sciences; Metabolic diseases; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Neural Pathways - metabolism; Neural Pathways - physiopathology; Obesity; Obesity - drug therapy; Obesity - metabolism; Obesity - physiopathology; Reviews; Time Factors; Treatment Outcome; Vertebrates: nervous system and sense organs; Weight control; Weight Gain; Weight Loss
• ISSN: 0363-6119; 1522-1490
• DOI: 10.1152/ajpregu.00755.2010

Dieting is the most common approach to losing weight for the majority of obese and overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself, dieting has a relatively poor success rate for long-term weight reduction. Most obese people eventually regain the weight they have worked so hard to lose. Weight regain has emerged as one of the most significant obstacles for obesity therapeutics, undoubtedly perpetuating the epidemic of excess weight that now affects more than 60% of U.S. adults. In this review, we summarize the evidence of biology's role in the problem of weight regain. Biology's impact is first placed in context with other pressures known to affect body weight. Then, the biological adaptations to an energy-restricted, low-fat diet that are known to occur in the overweight and obese are reviewed, and an integrative picture of energy homeostasis after long-term weight reduction and during weight regain is presented. Finally, a novel model is proposed to explain the persistence of the "energy depletion" signal during the dynamic metabolic state of weight regain, when traditional adiposity signals no longer reflect stored energy in the periphery. The preponderance of evidence would suggest that the biological response to weight loss involves comprehensive, persistent, and redundant adaptations in energy homeostasis and that these adaptations underlie the high recidivism rate in obesity therapeutics. To be successful in the long term, our strategies for preventing weight regain may need to be just as comprehensive, persistent, and redundant, as the biological adaptations they are attempting to counter.