A rare case of male breast ductal carcinoma in-situ associated with prolactinoma

A case of ductal carcinoma in-situ (DCIS) associated with prolactinoma in a male patient is described. A 56-year-old gentleman presented with lethargy and loss of libido. His prolactin at presentation was 3680 mU/l and an MRI scan of the head revealed a pituitary tumour suggestive of prolactinoma. F...

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Bibliographic Details
Published in:BMJ case reports 2011-08, Vol.2011 (aug31 1), p.bcr0120091421-bcr0120091421
Main Authors: Mallawaarachchi, Chandike Maithri, Ivanova, Snezana, Shorthouse, Alice, Shousha, Sami, Sinnett, Dudley
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms, Male - diagnostic imaging
Breast Neoplasms, Male - pathology
Breast Neoplasms, Male - surgery
Cancer therapies
Carcinoma in Situ - diagnostic imaging
Carcinoma in Situ - pathology
Carcinoma in Situ - surgery
Coronary vessels
Europe (West)
Family medical history
Histology
Humans
Male
Males
Mammography
Mastectomy
Metastasis
Middle Aged
Pituitary Neoplasms - diagnostic imaging
Pituitary Neoplasms - pathology
Pituitary Neoplasms - surgery
Prolactinoma - diagnostic imaging
Prolactinoma - pathology
Prolactinoma - surgery
Surgery
Ultrasonography
Unusual Association of Diseases/Symptoms
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Summary:A case of ductal carcinoma in-situ (DCIS) associated with prolactinoma in a male patient is described. A 56-year-old gentleman presented with lethargy and loss of libido. His prolactin at presentation was 3680 mU/l and an MRI scan of the head revealed a pituitary tumour suggestive of prolactinoma. Following 18 months of treatment with cabergoline, the prolactin level reduced to 914 mU/l. However, 3 years later he presented with blood stained nipple discharge, the cytology of which was negative for cancer. Ultrasound scan of his right breast revealed a single dilated mammary duct. Microdochectomy was performed. The histology revealed incompletely excised DCIS. There is increasing evidence of prolactinoma associated with breast cancer with or without DCIS in females. A review of the literature reveals only one previous case report of this association in males. This is the first case of pure DCIS preceded by prolactinoma in a male patient.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr.01.2009.1421