Nucleotide sequence of a cDNA encoding a larval α-globin chain of the amphibian Pleurodeles waltlii

In the amphibian Pleurodeles waltlii , hemoglobin undergoes an ontogenic switch from larval to adult forms. This switch is inducible by thyroid hormones and represents an attractive system to study the regulation of the sequential activation of the globin genes during erythroid differentiation. The...

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Bibliographic Details
Published in:Nucleic acids research 1989-04, Vol.17 (7), p.2850-2850
Main Authors: FLAVIN, M, VALENTIN, C, MEUNIER-ROTIVAL, M, COHEN-SOLAL, M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
DNA - isolation & purification
Fundamental and applied biological sciences. Psychology
genes
Genes. Genome
Globins - genetics
Larva - analysis
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Pleurodeles - genetics
Pleurodeles waltlii
Salamandridae - genetics
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Summary:In the amphibian Pleurodeles waltlii , hemoglobin undergoes an ontogenic switch from larval to adult forms. This switch is inducible by thyroid hormones and represents an attractive system to study the regulation of the sequential activation of the globin genes during erythroid differentiation. The authors have previously constructed a library of erythrocyte cDNAs from larvae of Pleurodeles waltlii at a stage where larval and adult globin genes are expressed simultaneously. The clones corresponding to larval or adult genes were separated by differential screening and identified by hybridization selection and in vitro translation of the selected mRNAs. They report here the sequence of an alpha -globin cDNA found only at early stages of development.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/17.7.2850