Klotho is silenced through promoter hypermethylation in gastric cancer

As one of major epigenetic changes to inactivate tumor suppressor genes in human carcinogenesis, promoter hypermethylation was proposed as a marker to define novel tumor suppressor genes and predict the prognosis of cancer patients. In the present study, we found KL (klotho) as a novel tumor suppres...

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Published in:American journal of cancer research 2011-01, Vol.1 (1), p.111-119
Main Authors: Wang, Liangjing, Wang, Xian, Wang, Xiaojia, Jie, Pan, Lu, Haiqi, Zhang, Shengjie, Lin, Xiaoying, Lam, Emily Ky, Cui, Yan, Yu, Jun, Jin, Hongchuan
Format: Article
Language:English
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Summary:As one of major epigenetic changes to inactivate tumor suppressor genes in human carcinogenesis, promoter hypermethylation was proposed as a marker to define novel tumor suppressor genes and predict the prognosis of cancer patients. In the present study, we found KL (klotho) as a novel tumor suppressor gene silenced through promoter hypermethylation in gastric cancer, the second leading cause of cancer death worldwide. KL expression was downregulated in primary gastric carcinoma tissues (n=22, p
ISSN:2156-6976
2156-6976