Novel roles for hERG K+ channels in cell proliferation and apoptosis

The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K + channels are al...

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Bibliographic Details
Published in:Cell death & disease 2011-08, Vol.2 (8), p.e193-e193
Main Authors: Jehle, J, Schweizer, P A, Katus, H A, Thomas, D
Format: Article
Language:English
Subjects:
631/136/2091
631/45/269/1151
631/80/82/23
692/699/67/1059
Antibodies
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell Proliferation - drug effects
Ether-A-Go-Go Potassium Channels - antagonists & inhibitors
Ether-A-Go-Go Potassium Channels - metabolism
Humans
Immunology
Life Sciences
Neoplasms - metabolism
Potassium Channel Blockers - pharmacology
Review
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Summary:The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K + channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K + channels as future drug target in anticancer therapy is highlighted.
ISSN:2041-4889
2041-4889
DOI:10.1038/cddis.2011.77