A case of acute renal failure in a patient recently treated with clozapine and a review of previously reported cases

Clozapine has been reported to cause acute renal failure due to acute interstitial nephritis. We discuss a case of clozapine-induced acute renal failure and compare it to 7 other cases reported in the literature. We review the signs and symptoms of the hypersensitivity response, such as fever and eo...

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Bibliographic Details
Published in:Primary care companion for CNS disorders 2011, Vol.13 (3)
Main Authors: Kanofsky, J Daniel, Woesner, Mary E, Harris, Alexander Z, Kelleher, James P, Gittens, Karen, Jerschow, Elina
Format: Article
Language:English
Subjects:
Brief Report
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Summary:Clozapine has been reported to cause acute renal failure due to acute interstitial nephritis. We discuss a case of clozapine-induced acute renal failure and compare it to 7 other cases reported in the literature. We review the signs and symptoms of the hypersensitivity response, such as fever and eosinophilia, caused by clozapine and make recommendations for early detection. Early detection and prompt discontinuation of clozapine can prevent renal damage, as can the avoidance of other nephrotoxic drugs like antibiotics.
ISSN:2155-7772
2155-7780
DOI:10.4088/PCC.10br01091