DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4 + T cells, but few subdominant epitope-specific CD8 + T cells

Highlights► In this study, we attempt to elicit CD8+ T cell responses against subdominant epitopes and CD4+ T cell responses. ► We conclude that it is relatively straightforward to elicit CD4+ T cell responses against SIV epitopes. ► Eliciting CD8+ T cell responses against subdominant SIV epitopes i...

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Bibliographic Details
Published in:Vaccine 2011-10, Vol.29 (43), p.7483-7490
Main Authors: Vojnov, Lara, Bean, Alexander T, Peterson, Eric J, Chiuchiolo, Maria J, Sacha, Jonah B, Denes, Ferencz S, Sandor, Matyas, Fuller, Deborah H, Fuller, James T, Parks, Christopher L, McDermott, Adrian B, Wilson, Nancy A, Watkins, David I
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Allergy and Immunology
Animals
Antigens, Viral - immunology
Applied microbiology
Biological and medical sciences
CD4+ T cells
CD4-positive T-lymphocytes
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
CD8+ T cells
CD8-positive T-lymphocytes
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
Colleges & universities
Deoxyribonucleic acid
DNA
DNA/Ad5 vaccination
epitopes
Epitopes, T-Lymphocyte - immunology
Fundamental and applied biological sciences. Psychology
Histocompatibility Antigens Class I - immunology
HIV
Human immunodeficiency virus
Immune system
Immunodominant Epitopes
Infections
Interleukin-12
Lymphocyte Activation
Lymphocytes
Macaca mulatta
Microbiology
Miscellaneous
Peptides
Plasmids
Simian Acquired Immunodeficiency Syndrome - genetics
Simian Acquired Immunodeficiency Syndrome - immunology
Simian Acquired Immunodeficiency Syndrome - prevention & control
Simian Immunodeficiency Virus - genetics
Simian Immunodeficiency Virus - immunology
Subdominant epitopes
T cell receptors
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, DNA - administration & dosage
Vaccines, DNA - immunology
Viral Proteins - immunology
Virology
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Summary:Highlights► In this study, we attempt to elicit CD8+ T cell responses against subdominant epitopes and CD4+ T cell responses. ► We conclude that it is relatively straightforward to elicit CD4+ T cell responses against SIV epitopes. ► Eliciting CD8+ T cell responses against subdominant SIV epitopes is far more difficult than previously believed.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.07.048