Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study

The long-term pathological effects of chronic epilepsy on normal brain ageing are unknown. Previous clinical and epidemiological studies show progressive cognitive decline in subsets of patients and an increased prevalence of Alzheimer's disease in epilepsy. In a post-mortem series of 138 patie...

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Bibliographic Details
Published in:Brain (London, England : 1878) England : 1878), 2011-10, Vol.134 (10), p.2969-2981
Main Authors: Thom, Maria, Liu, Joan Y.W., Thompson, Pam, Phadke, Rahul, Narkiewicz, Marta, Martinian, Lillian, Marsdon, Derek, Koepp, Matthias, Caboclo, Luis, Catarino, Claudia B., Sisodiya, Sanjay M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Astrocytes - metabolism
Astrocytes - pathology
Biological and medical sciences
Brain Injuries - metabolism
Brain Injuries - pathology
Disease Progression
Epilepsy - metabolism
Epilepsy - pathology
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampus - metabolism
Hippocampus - pathology
Humans
Injuries of the nervous system and the skull. Diseases due to physical agents
Male
Medical sciences
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nervous system (semeiology, syndromes)
Neurofibrillary Tangles - metabolism
Neurofibrillary Tangles - pathology
Neurology
Original
Sclerosis
tau Proteins - metabolism
Traumas. Diseases due to physical agents
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Summary:The long-term pathological effects of chronic epilepsy on normal brain ageing are unknown. Previous clinical and epidemiological studies show progressive cognitive decline in subsets of patients and an increased prevalence of Alzheimer's disease in epilepsy. In a post-mortem series of 138 patients with long-term, mainly drug-resistant epilepsy, we carried out Braak staging for Alzheimer's disease neurofibrillary pathology using tau protein immunohistochemistry. The stages were compared with clinicopathological factors, including seizure history and presence of old traumatic brain injury. Overall, 31% of cases were Braak Stage 0, 36% Stage I/II, 31% Stage III/IV and 2% Stage V/VI. The mean age at death was 56.5 years and correlated with Braak stage (P 
ISSN:0006-8950
1460-2156
DOI:10.1093/brain/awr209