Long-term respiratory symptoms following oesophageal atresia

Background:  Oesophageal atresia (OA) is a congenital malformation that can lead to persistent respiratory symptoms in adulthood. Aim:  To describe the prevalence of respiratory symptoms in adulthood in a population‐based study of patients with repaired OA and to compare this with the prevalence in...

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Bibliographic Details
Published in:Acta Paediatrica 2011-09, Vol.100 (9), p.1222-1225
Main Authors: Gatzinsky, Vladimir, Jönsson, Linus, Ekerljung, Linda, Friberg, Lars-Göran, Wennergren, Göran
Format: Article
Language:English
Subjects:
Adult
Asthma
Biological and medical sciences
Chronic obstructive pulmonary disease, asthma
Confidence Intervals
Esophageal Atresia - complications
Esophageal Atresia - pathology
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Lung Diseases - diagnosis
Lung Diseases - epidemiology
Lung Diseases - pathology
Male
Malformations
Medical sciences
Odds Ratio
Oesophageal atresia
Outcome
Pneumology
Prevalence
Registries
Regular
Respiratory diseases
Respiratory Sounds
Respiratory symptoms
Risk Factors
Surveys and Questionnaires
Sweden - epidemiology
Time Factors
Treatment Outcome
Wheezing
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Summary:Background:  Oesophageal atresia (OA) is a congenital malformation that can lead to persistent respiratory symptoms in adulthood. Aim:  To describe the prevalence of respiratory symptoms in adulthood in a population‐based study of patients with repaired OA and to compare this with the prevalence in the general population. Methods:  Of 80 patients operated for OA in Gothenburg in 1968–1983, 79 were located. The patients received a questionnaire on respiratory symptoms. Controls were 4979 gender‐ and age‐matched subjects who answered the same questions. Results:  The questionnaire was answered by 73 of 79 (92%) patients. Physician‐diagnosed asthma was reported by 30% in the OA group vs 10% in the control group (OR 4.1; 95% CI 2.4–6.8), and recurrent wheeze in 29% vs 5.5% (OR 6.9; 4.1–11.6). Also wheeze during the last year, asthma medication, a long‐standing cough, cough with sputum production and chronic bronchitis were significantly more common among the patients with OA. In contrast, there was no significant difference regarding risk factors for asthma. The prevalence of respiratory symptoms did not appear to decrease with age. Conclusion:  A high prevalence of respiratory symptoms remains among adult patients with repaired OA. Many of the patients had an asthma diagnosis. However, asthma heredity or allergic rhinitis was not overrepresented.
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2011.02279.x