A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers

ObjectivesTo study possible effects of aerosol exposure on lung function, fractional exhaled nitric oxide (FeNO) and inflammatory markers in blood from Norwegian cement production workers across one work shift (0 to 8 h) and again 32 h after the non-exposed baseline registration.Methods95 workers fr...

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Bibliographic Details
Published in:Occupational and environmental medicine (London, England) England), 2011-11, Vol.68 (11), p.799-805
Main Authors: Fell, Anne Kristin M, Notø, Hilde, Skogstad, Marit, Nordby, Karl-Christian, Eduard, Wijnand, Svendsen, Martin Veel, Øvstebø, Reidun, Trøseid, Anne Marie Siebke, Kongerud, Johny
Format: Article
Language:English
Subjects:
Adult
Aerosols
Air Pollutants, Occupational - toxicity
Asthma
Biological and medical sciences
Biomarkers - blood
Blood
Blue collar workers
Cement
Cements
Chemical and industrial products toxicology. Toxic occupational diseases
Chronic obstructive pulmonary disease
Construction Materials - toxicity
Cross-sectional studies
Dust
Epidemiology
exposure assessment
Female
Fibrinogen - metabolism
Forced Expiratory Flow Rates
Forced Expiratory Volume
Gaseous diffusion
Humans
immunology
inorganic dusts
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Interleukin-10 - blood
Leukocyte Count
Leukocytes
lung function
Lungs
Male
Mechanical ventilators
Medical sciences
Nitric oxide
Nitric Oxide - blood
Occupational exposure
Occupational Exposure - adverse effects
Oxides
Production workers
Respiratory function
Spirometry
Tobacco smoking
Toxicology
Tumor Necrosis Factor-alpha - blood
Tumor necrosis factor-TNF
Workplace
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Summary:ObjectivesTo study possible effects of aerosol exposure on lung function, fractional exhaled nitric oxide (FeNO) and inflammatory markers in blood from Norwegian cement production workers across one work shift (0 to 8 h) and again 32 h after the non-exposed baseline registration.Methods95 workers from two cement plants in Norway were included. Assessment of lung function included spirometry and gas diffusion pre- and post-shift (0 and 8 h). FeNO concentrations were measured and blood samples collected at 0, 8 and 32 h. Blood analysis included cell counts of leucocytes and mediators of inflammation.ResultsThe median respirable aerosol level was 0.3 mg/m3 (range 0.02–6.2 mg/m3). FEV1, FEF25–75% and DLCO decreased by 37 ml (p=0.04), 170 ml/s (p
ISSN:1351-0711
1470-7926
DOI:10.1136/oem.2010.057729