In vivo cancer imaging by poly(ethylene glycol)- b -poly(ɛ-caprolactone) micelles containing a near-infrared probe

Abstract Noninvasive near-infrared (NIR) fluorescence imaging is a promising technique for the intraoperative assessment of solid tumor removal. We incorporated a lipophilic NIR probe, 1,1′-dioctadecyltetramethyl indotricarbocyanine iodide (DiR), in poly(ethylene glycol)- b -poly(ɛ-caprolactone) (PE...

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Bibliographic Details
Published in:Nanomedicine 2012-02, Vol.8 (2), p.228-236
Main Authors: Cho, Hyunah, MS, Indig, Guilherme L., PhD, Weichert, Jamey, PhD, Shin, Ho-Chul, MS, Kwon, Glen S., PhD
Format: Article
Language:English
Subjects:
Carbocyanines - chemistry
Diagnostic Imaging - methods
Fluorescent Dyes - chemistry
Humans
Internal Medicine
Micelles
Near infrared (NIR) fluorescence imaging
Neoplasms - diagnosis
Particle Size
Poly(ethylene glycol)- b-poly(ɛ-caprolactone)
Polyesters - chemistry
Polyethylene Glycols - chemistry
Polymeric micelles
Self-quenching
Solubility
Water
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Summary:Abstract Noninvasive near-infrared (NIR) fluorescence imaging is a promising technique for the intraoperative assessment of solid tumor removal. We incorporated a lipophilic NIR probe, 1,1′-dioctadecyltetramethyl indotricarbocyanine iodide (DiR), in poly(ethylene glycol)- b -poly(ɛ-caprolactone) (PEG- b -PCL) micelles, resulting in DiR solubilization in water, occupying nanoscopic PEG- b -PCL micelles. DiR in a self-quenched or nonquenched state showed different kinetics of release from PEG- b -PCL micelles in vitro; however, both obtained high tumor delineation (tumor-to-muscle ratio of 30–43 from collected organs). These results suggest that PEG- b -PCL micelles with DiR are a promising nanosized imaging agent that will provide a basis for enhanced surgical guidance via NIR visualization of tumors. From the Clinical Editor In this paper, noninvasive near-infrared fluorescence imaging coupled with specific lipophilic probes is discussed as a promising technique for intraoperative assessment of solid tumor removal, leading to optimized outcomes for in toto removal of tumors.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2011.06.009