Balancing act: deubiquitinating enzymes in the nervous system

Many pathways important to the nervous system are regulated by the post-translational conjugation of ubiquitin to target proteins. The reversal of ubiquitination, or deubiquitination, is equally critical to neuronal function. By countering protein ubiquitination, deubiquitinating enzymes (DUBs) help...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2011-07, Vol.34 (7), p.370-382
Main Authors: Todi, Sokol V, Paulson, Henry L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cells
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Human viral diseases
Humans
Infectious diseases
Medical sciences
Nervous system
Nervous System - enzymology
Neurological disorders
Neurology
Neurons - enzymology
Proteins
Ubiquitin-Specific Proteases - physiology
Ubiquitination - physiology
Vertebrates: nervous system and sense organs
Viral diseases
Viral diseases of the nervous system
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Summary:Many pathways important to the nervous system are regulated by the post-translational conjugation of ubiquitin to target proteins. The reversal of ubiquitination, or deubiquitination, is equally critical to neuronal function. By countering protein ubiquitination, deubiquitinating enzymes (DUBs) help control neuronal fate determination, axonal pathfinding and synaptic communication and plasticity. The significance of DUBs to the nervous system is underscored by links to various neurological diseases. Owing to cell type or substrate specificity, certain DUBs might also represent therapeutic targets for neurodegeneration. Here, we review recent findings that have shaped our current understanding of emerging functions for DUBs in the nervous system.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2011.05.004