Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2

The three members of the amyloid precursor protein family in mammals [amyloid precursor protein, amyloid precursor-like protein 1, and amyloid precursor-like protein 2 (APLP2)] have been implicated in a large array of intracellular processes, which include development, transcription, apoptosis, meta...

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Bibliographic Details
Published in:Immunologic research 2011-10, Vol.51 (1), p.39-44
Main Authors: Peters, Haley L., Tuli, Amit, Sharma, Mahak, Naslavsky, Naava, Caplan, Steve, MacDonald, Richard G., Solheim, Joyce C.
Format: Article
Language:English
Subjects:
Allergology
Alzheimer's disease
Amyloid
Amyloid beta-Protein Precursor - immunology
Amyloid beta-Protein Precursor - metabolism
Amyloid precursor protein
Animals
Antigen presentation
Apoptosis
beta -Amyloid
Biomedical and Life Sciences
Biomedicine
Cancer
Cell cycle
Endocytosis
Gene expression
Gene Expression Regulation, Neoplastic - immunology
Histocompatibility Antigens Class I - biosynthesis
Histocompatibility Antigens Class I - immunology
Humans
Immune system
Immunology
Internal Medicine
Major histocompatibility complex
Medicine/Public Health
Molecular biology
Neoplasm Proteins - immunology
Neoplasm Proteins - metabolism
Neoplasms - immunology
Neoplasms - metabolism
Nerve Tissue Proteins - immunology
Nerve Tissue Proteins - metabolism
Pancreatic cancer
Protein turnover
Signal transduction
Transcription
Tumor cell lines
Tumors
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Summary:The three members of the amyloid precursor protein family in mammals [amyloid precursor protein, amyloid precursor-like protein 1, and amyloid precursor-like protein 2 (APLP2)] have been implicated in a large array of intracellular processes, which include development, transcription, apoptosis, metabolism, and the cell cycle. A series of studies by our laboratories has demonstrated that APLP2 is highly expressed by many cancer cell lines (with the highest expression in pancreatic cancer cell lines) and that it facilitates major histocompatibility complex (MHC) class I molecule endocytosis. This review focuses on this recently revealed function of APLP2 relevant to tumor immunology: that it acts as a novel regulator of MHC class I molecule surface expression.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-011-8238-6