Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study

Aims To investigate the role of medication in 20-year trends in blood pressure (BP) and blood lipids in older British men. Methods and results BP and lipids were measured in 4231 men from a representative cohort at baseline (1978–1980, aged 40–59 years) and after 20 years (1998–2000). Cohort-wide ag...

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Bibliographic Details
Published in:European journal of cardiovascular prevention and rehabilitation 2010-10, Vol.17 (5), p.502-508
Main Authors: Hardoon, Sarah L., Whincup, Peter H., Goya Wannamethee, S., Lennon, Lucy T., Capewell, Simon, Morris, Richard W.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Antihypertensive Agents - therapeutic use
Biomarkers - blood
Blood Pressure - drug effects
Cholesterol - blood
Cholesterol, HDL - blood
Cohort Studies
Coronary Artery Disease - epidemiology
Coronary Artery Disease - etiology
Coronary Artery Disease - prevention & control
Drug Utilization
Dyslipidemias - blood
Dyslipidemias - complications
Dyslipidemias - drug therapy
Dyslipidemias - epidemiology
Health Behavior
Humans
Hypertension - complications
Hypertension - drug therapy
Hypertension - epidemiology
Hypertension - physiopathology
Hypolipidemic Agents - therapeutic use
Linear Models
Male
Middle Aged
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
United Kingdom - epidemiology
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Summary:Aims To investigate the role of medication in 20-year trends in blood pressure (BP) and blood lipids in older British men. Methods and results BP and lipids were measured in 4231 men from a representative cohort at baseline (1978–1980, aged 40–59 years) and after 20 years (1998–2000). Cohort-wide age-adjusted 20-year mean changes were as follows: systolic BP – 7.6mmHg (95% confidence interval: – 9.7 to – 5.4); diastolic BP + 3.3mmHg (+2.2 to + 4.5); nonhigh-density lipoprotein (HDL)-cholesterol – 0.4 mmol/l (– 0.5 to – 0.2); HDL-cholesterol +0.16 mmol/l (+ 0.13 to + 0.19). Much (79%) of the systolic BP fall occurred only among 1561 men (37%) reporting the use of BP-lowering medication during the follow-up; systolic BP changed by – 12.3mmHg (− 14.7 to – 9.9) and – 1.6mmHg (– 3.7 to + 0.5) among medication users and men not using medication, respectively (P
ISSN:2047-4873
1741-8267
1741-8275
2047-4881
1741-8275
DOI:10.1097/HJR.0b013e3283378865