Cefotaxime-induced near-fatal anaphylaxis in a neonate: A case report and review of literature

A case of 7-day-old male neonate with cefotaxime-induced near-fatal anaphylaxis is being reported. Child was started on intravenous cefotaxime on day 3 of life in view of early-onset sepsis with pneumonia, following which there was clinical improvement. Child was then shifted out of intensive care t...

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Bibliographic Details
Published in:Indian journal of pharmacology 2011-09, Vol.43 (5), p.611-612
Main Authors: Babu, Thirunavukkarasu Arun, Sharmila, Vijayan
Format: Article
Language:English
Subjects:
Anaphylaxis
Antibiotics
Care and treatment
Case studies
Cefotaxime
Children & youth
Complications and side effects
Diagnosis
Dosage and administration
Drug Watch
Patient outcomes
Pharmacology
Pneumonia
Risk factors
Sepsis
Side effects
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Summary:A case of 7-day-old male neonate with cefotaxime-induced near-fatal anaphylaxis is being reported. Child was started on intravenous cefotaxime on day 3 of life in view of early-onset sepsis with pneumonia, following which there was clinical improvement. Child was then shifted out of intensive care to general ward for completion of antibiotic course. One day prior to the planned discharge, child suddenly developed poor sensorium, flaccidity, apnea, and cyanosis within seconds of receiving intravenous cefotaxime and was found to have bradypnea with bradycardia. Prompt resuscitation was carried out with artificial ventilation, adrenaline, and steroids. Spontaneous breathing reappeared and the clinical condition improved.
ISSN:0253-7613
1998-3751
DOI:10.4103/0253-7613.84987