New 30-valent M protein-based vaccine evokes cross-opsonic antibodies against non-vaccine serotypes of group A streptococci

Highlights ► A new recombinant 30-valent M protein-based group A streptococcal vaccine. ► Vaccine design based on current epidemiology of pharyngeal and invasive infections. ► Bactericidal antibodies evoked against all vaccine serotypes of streptococci. ► Vaccine antisera were bactericidal against a...

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Bibliographic Details
Published in:Vaccine 2011-10, Vol.29 (46), p.8175-8178
Main Authors: Dale, James B, Penfound, Thomas A, Chiang, Edna Y, Walton, William J
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies
Antibodies, Bacterial - blood
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
Antisera
antiserum
Applied microbiology
Bacterial Outer Membrane Proteins - genetics
Bacterial Outer Membrane Proteins - immunology
Bacteriology
Biological and medical sciences
Blood Bactericidal Activity
Carrier Proteins - genetics
Carrier Proteins - immunology
Colleges & universities
Cross Reactions
Design
double prime M protein
Epidemiology
Europe
Fundamental and applied biological sciences. Psychology
Group A streptococci
humans
Immunogenicity
Infections
M protein
Microbiology
Miscellaneous
North America
Opsonin Proteins - blood
Peptides
Proteins
Rabbits
Serotypes
Streptococcal Vaccines - administration & dosage
Streptococcal Vaccines - immunology
Streptococcus
Streptococcus pyogenes - immunology
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - immunology
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Summary:Highlights ► A new recombinant 30-valent M protein-based group A streptococcal vaccine. ► Vaccine design based on current epidemiology of pharyngeal and invasive infections. ► Bactericidal antibodies evoked against all vaccine serotypes of streptococci. ► Vaccine antisera were bactericidal against a number of non-vaccine serotypes.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.09.005