IFN-λs

Highlights ► The interferon (IFN) family was recently expanded with the discovery of type III IFNs. ► Type III IFNs or IFN-λs, also known as IL-28/29, are directly induced by viral infection. ► IFN-λs, together with type I IFNs, function as early mediators of the innate antiviral response. ► IFN-λs...

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Bibliographic Details
Published in:Current opinion in immunology 2011-10, Vol.23 (5), p.583-590
Main Author: Kotenko, Sergei V
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Chromosomes, Human, Pair 19 - chemistry
Chromosomes, Human, Pair 19 - immunology
Exons
Gene Expression Regulation - immunology
Humans
Immunity, Innate
Interferon-alpha - genetics
Interferon-alpha - immunology
Interferon-alpha - metabolism
Interferon-beta - genetics
Interferon-beta - immunology
Interferon-beta - metabolism
Interferons
Interleukins - genetics
Interleukins - immunology
Interleukins - metabolism
Intestinal Mucosa - immunology
Intestinal Mucosa - virology
Introns
Mice
Multigene Family
Organ Specificity
Receptors, Interferon - genetics
Receptors, Interferon - immunology
Receptors, Interferon - metabolism
Signal Transduction - immunology
Virus Diseases - immunology
Virus Diseases - virology
Viruses - immunology
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Description
Summary:Highlights ► The interferon (IFN) family was recently expanded with the discovery of type III IFNs. ► Type III IFNs or IFN-λs, also known as IL-28/29, are directly induced by viral infection. ► IFN-λs, together with type I IFNs, function as early mediators of the innate antiviral response. ► IFN-λs engage a specific receptor complex to induce antiviral state in cells. ► IFN-λs possess unique biological activities in and beyond innate antiviral immunity.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2011.07.007