Pneumonia and influenza hospitalization in HIV-positive seniors

• Published in: Epidemiology and infection 2011-09, Vol.139 (9), p.1317-1325
• Main Authors: MOR, S. M., AMINAWUNG, J. A., DEMARIA, A., NAUMOVA, E. N.
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Age; Age Factors; Aged; Aged, 80 and over; Aging; AIDS; Biological and medical sciences; Cardiovascular disease; Community-Acquired Pneumonia and Bacteraemia; Demographics; Fatalities; Female; Fundamental and applied biological sciences. Psychology; Gender; Generalized linear models; Highly active antiretroviral therapy; HIV; HIV infections; HIV Infections - complications; Hospitalization; Human immunodeficiency virus; Human viral diseases; Humans; Infections; Infectious diseases; Influenza; Influenza, Human - mortality; Male; Medical sciences; Medicare; Microbiology; Older adults; Older people; Original Papers; Patients; Pneumonia; Pneumonia - mortality; Risk Factors; Trends; United States - epidemiology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S0950268810002669

HIV-positive persons and the elderly have increased risk for influenza-related complications, including pneumonia. Using claims data for pneumonia and influenza (P&I) hospitalization in the USA, we described the temporo-demographic trends and in-patient case-fatality in persons aged ≥65 years by HIV status. Our results showed a near doubling in the fraction of P&I admissions representing HIV-positive persons between 1991 and 2004 [relative risk (RR) 1·95, 95% confidence interval (CI) 1·80–2·13]. HIV-positive adults were younger (70·3 vs. 79·9 years, P < 0·001), and had higher case-fatality (18·0% vs. 12·6%, P