Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation

The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-5
Main Authors: Bersani-Amado, Ciomar Aparecida, Caparroz-Assef, Silvana Martins, Truiti, Maria da Conceição Torrado, Baroni, Silmara, de Arruda, Laura Lícia Milani, de Melo, Juliana Oliveira, Cuman, Roberto Kenji Nakamura
Format: Article
Language:English
Subjects:
Body weight
Carrageenan
Diabetes
Edema
Endothelium
Ethanol
Exudation
Granulocytes
Helicteres
Inflammation
Injection
Leukocyte migration
Leukocytes (polymorphonuclear)
Neutrophils
Permeability
Physiology
Pleural cavity
Pleurisy
Rodents
Vinegar
Weight reduction
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Summary:The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.
ISSN:1741-427X
1741-4288
DOI:10.1155/2012/141947