Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation

The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of...

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Published in:Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-5
Main Authors: Bersani-Amado, Ciomar Aparecida, Caparroz-Assef, Silvana Martins, Truiti, Maria da Conceição Torrado, Baroni, Silmara, de Arruda, Laura Lícia Milani, de Melo, Juliana Oliveira, Cuman, Roberto Kenji Nakamura
Format: Article
Language:English
Subjects:
Body weight
Carrageenan
Diabetes
Edema
Endothelium
Ethanol
Exudation
Granulocytes
Helicteres
Inflammation
Injection
Leukocyte migration
Leukocytes (polymorphonuclear)
Neutrophils
Permeability
Physiology
Pleural cavity
Pleurisy
Rodents
Vinegar
Weight reduction
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creator Bersani-Amado, Ciomar Aparecida
Caparroz-Assef, Silvana Martins
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de Arruda, Laura Lícia Milani
de Melo, Juliana Oliveira
Cuman, Roberto Kenji Nakamura
description The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.
doi_str_mv 10.1155/2012/141947
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Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). 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subjects Body weight
Carrageenan
Diabetes
Edema
Endothelium
Ethanol
Exudation
Granulocytes
Helicteres
Inflammation
Injection
Leukocyte migration
Leukocytes (polymorphonuclear)
Neutrophils
Permeability
Physiology
Pleural cavity
Pleurisy
Rodents
Vinegar
Weight reduction
title Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation
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