Quantitative genetics of disease resistance in vaccinated and unvaccinated Atlantic salmon ( L.)

• Published in: Heredity 2011-10, Vol.107 (5), p.471-477
• Main Authors: Drangsholt, T M K, Gjerde, B, Ødegård, J, Finne-Fridell, F, Evensen, Ø, Bentsen, H B
• Format: Article
• Language: English
• Subjects: 631/208/727/2000; 631/250/251/1567; 631/326/590; 692/699/255/1318; Animal diseases; Animals; Biomedical and Life Sciences; Biomedicine; Birnaviridae Infections - genetics; Birnaviridae Infections - immunology; Birnaviridae Infections - veterinary; Body Weight; Cohabitation; Cytogenetics; Disease Resistance; Ecology; Evolutionary Biology; Female; Fish; Furunculosis - genetics; Furunculosis - immunology; Furunculosis - prevention & control; Furunculosis - veterinary; Genetic Association Studies; Genetic diversity; Genetic improvement; Genetics; Heredity; Human Genetics; Immunity, Innate; Male; Marine; Models, Genetic; Original; original-article; Orthomyxoviridae Infections - genetics; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - veterinary; Plant Genetics and Genomics; Quantitative genetics; Salmo salar; Salmon; Selective breeding; Survival Analysis; Vaccination - veterinary; Vaccines; Viral diseases
• ISSN: 0018-067X; 1365-2540
• DOI: 10.1038/hdy.2011.34

Furunculosis ( Aeromonoas salmonicida ) is an important disease in Atlantic salmon ( Salmo salar ) farming. Vaccination and selective breeding for increased resistance to the disease on the basis of challenge tests of unvaccinated fish are used as complementary prophylactic methods. An important issue is whether genetic predisposition to infection is consistent across vaccinated and unvaccinated fish. Hence, the main objective of this study was to determine the magnitude of the genetic associations (correlations) between resistance to furunculosis in vaccinated and unvaccinated fish, and to estimate the magnitude of the correlation of resistance to furunculosis with resistance to the viral diseases infectious pancreatic necrosis (IPN) and infectious salmon anaemia (ISA). Sub-samples of unvaccinated and vaccinated salmon from 150 full-sib families were subjected to separate cohabitation challenge tests. Substantial genetic variation was found in resistance to furunculosis in both the unvaccinated (heritabilities of 0.51±0.05) and vaccinated (0.39±0.06) fish. However, the genetic correlation between resistance to furunculosis in the two groups was low (0.32±0.13), indicating a weak genetic association between resistance in the two groups. Hence, the current selection strategy on the basis of challenge tests of unvaccinated fish is likely to produce low genetic improvement in resistance to furunculosis under field conditions, where fish are vaccinated with an effective vaccine. Evidence was found of significantly favourable genetic associations of resistance to furunculosis in unvaccinated (but less so for vaccinated) fish with resistance to both IPN and ISA (unvaccinated fish), indicating that vaccination ‘mask’ genetic associations between resistance to different diseases.