Isl1 Is required for multiple aspects of motor neuron development

The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in oth...

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Bibliographic Details
Published in:Molecular and cellular neuroscience 2011-07, Vol.47 (3), p.215-222
Main Authors: Liang, Xingqun, Song, Mi-Ryoung, Xu, ZengGuang, Lanuza, Guillermo M., Liu, Yali, Zhuang, Tao, Chen, Yihan, Pfaff, Samuel L., Evans, Sylvia M., Sun, Yunfu
Format: Article
Language:English
Subjects:
Animals
Axon growth
Axons - metabolism
Cell death
Cranial ganglia
Embryonic Development - physiology
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Isl1
LIM-Homeodomain Proteins
Mice
Mice, Transgenic
Motor neuron
Motor Neurons - metabolism
Spinal Cord - embryology
Spinal Cord - metabolism
Transcription Factors
V2 interneuron
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Summary:The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.
ISSN:1044-7431
1095-9327
DOI:10.1016/j.mcn.2011.04.007