Enhanced Mechanical Rigidity of Hydrogels Formed from Enantiomeric Peptide Assemblies

Chirality can be used as a design tool to control the mechanical rigidity of hydrogels formed from self-assembling peptides. Hydrogels prepared from enantiomeric mixtures of self-assembling β-hairpins show nonadditive, synergistic, enhancement in material rigidity compared to gels prepared from eith...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2011-09, Vol.133 (38), p.14975-14977
Main Authors: Nagy, Katelyn J, Giano, Michael C, Jin, Albert, Pochan, Darrin J, Schneider, Joel P
Format: Article
Language:English
Subjects:
Hydrogels - chemical synthesis
Hydrogels - chemistry
Models, Molecular
Particle Size
Peptides - chemical synthesis
Peptides - chemistry
Stereoisomerism
Surface Properties
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Summary:Chirality can be used as a design tool to control the mechanical rigidity of hydrogels formed from self-assembling peptides. Hydrogels prepared from enantiomeric mixtures of self-assembling β-hairpins show nonadditive, synergistic, enhancement in material rigidity compared to gels prepared from either pure enantiomer, with the racemic hydrogel showing the greatest effect. CD spectroscopy, TEM, and AFM indicate that this enhancement is defined by nanoscale interactions between enantiomers in the self-assembled state.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja206742m