Regulatory T Cells in Transplantation

Abstract T Regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance to self and alloantigens. Recent findings in experimental transplant models have demonstrated that Treg can control acute and delayed allograft rejection. Preclinical attempts to use...

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Bibliographic Details
Published in:Transplantation proceedings 2011-07, Vol.43 (6), p.2135-2136
Main Author: Wood, K.J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection - immunology
Graft Rejection - prevention & control
Graft Survival
Humans
Immune Tolerance
Isoantigens - immunology
Medical sciences
Organ Transplantation - adverse effects
Review
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
T-Lymphocytes, Regulatory - immunology
Tissue, organ and graft immunology
Transplantation Immunology
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Description
Summary:Abstract T Regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance to self and alloantigens. Recent findings in experimental transplant models have demonstrated that Treg can control acute and delayed allograft rejection. Preclinical attempts to use Treg as a cellular therapy have been successfully undertaken demonstrating the safety and feasibility of such treatment, suggesting that they have therapeutic potential.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.06.050