Antiretroviral Drug Resistance in HIV-1–Infected Patients Experiencing Persistent Low-Level Viremia During First-Line Therapy

Population sequencing was performed for persons identified with persistent low-level viremia in 2 clinical trials. Persistent low-level viremia (defined as plasma HIV-1 RNA level > 50 and < 1000 copies/mL in at least 2 determinations over a 24-week period, after at least 24 weeks of antiretrov...

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Bibliographic Details
Published in:The Journal of infectious diseases 2011-08, Vol.204 (4), p.515-520
Main Authors: Taiwo, Babafemi, Gallien, Sebastien, Aga, Evgenia, Ribaudo, Heather, Haubrich, Richard, Kuritzkes, Daniel R., Eron, Joseph J.
Format: Article
Language:English
Subjects:
Adult
AIDS
Antiretrovirals
Biological and medical sciences
Drug resistance
Drug Resistance, Viral - genetics
Female
Fundamental and applied biological sciences. Psychology
Genetic mutation
HIV 1
HIV Infections - blood
HIV Infections - drug therapy
HIV-1 - drug effects
HIV-1 - genetics
HIV/AIDS
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Major and Brief Reports
Male
Medical sciences
Microbiology
Mutation
Pretreatment
Retrospective Studies
Statistical median
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viremia
Viremia - blood
Viremia - virology
Virology
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Summary:Population sequencing was performed for persons identified with persistent low-level viremia in 2 clinical trials. Persistent low-level viremia (defined as plasma HIV-1 RNA level > 50 and < 1000 copies/mL in at least 2 determinations over a 24-week period, after at least 24 weeks of antiretroviral therapy) was observed in 65 (5.6%) of 1158 patients at risk. New resistance mutations were detected during persistent low-level viremia in 37% of the 54 evaluable cases. The most common mutations were M184I/V (14 cases), K103N (9), and M230L (3). Detection of new mutations was associated with higher HIV-1 RNA levels during persistent low-level viremia.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jir353